Abstract
Parkinson's disease (PD) is a neurodegenerative disease characterized by progressive loss of dopaminergic neurons in the basal ganglia. Single photon emission computed tomography (SPECT) scans using [99mTc]TRODAT-1 can image dopamine transporters and provide valuable diagnostic information of PD. In this study, we optimized the scanning parameters for [99mTc]TRODAT-1/SPECT using the Taguchi analysis to improve image quality. SPECT scans were performed on forty-five healthy volunteers according to an L9 orthogonal array. Three parameters were considered, including the injection activity, uptake duration, and acquisition time per projection. The signal-to-noise ratio (SNR) was calculated from the striatum/occipital activity ratio as an image quality index. Ten healthy subjects and fifteen PD patients were used to verify the optimal parameters. The estimated optimal parameters were 962 MBq for [99mTc]TRODAT-1 injection, 260 min for uptake duration, and 60 s/projection for data acquisition. The uptake duration and time per projection were the two dominant factors which had an F-value of 18.638 (38%) and 25.933 (53%), respectively. Strong cross interactions existed between the injection activity/uptake duration and injection activit...Continue Reading
References
Jan 3, 1997·Journal of Medicinal Chemistry·S K MeegallaH F Kung
Mar 7, 1998·European Journal of Nuclear Medicine·J BooijE A van Royen
Jan 29, 1999·Archives of Neurology·D J GelbS Gilman
Mar 22, 2001·Nuclear Medicine Communications·P F KaoG Ting
Apr 21, 2004·Nuclear Medicine Communications·Szu-Chia LaiChin-Song Lu
May 8, 2004·European Journal of Nuclear Medicine and Molecular Imaging·Wen-Sheng HuangShiaw-Pyng Wey
Jan 21, 2006·Physics in Medicine and Biology·Paul D ActonP David Mozley
Jun 8, 2006·Physics in Medicine and Biology·Paul D Acton, Andrew Newberg
Aug 9, 2006·Nuclear Medicine Communications·Christian la FougèreStefan Dresel
Aug 26, 2006·European Journal of Nuclear Medicine and Molecular Imaging·T Vander BorghtUNKNOWN European Association of Nuclear Medicine (EANM)
May 23, 2007·Clinical Nuclear Medicine·Chun-Yi LinChung-Hsin Yeh
Jul 13, 2007·Nuclear Medicine Communications·Walter KochKlaus Tatsch
Feb 6, 2008·Psychiatry Research·Wen-Juh HwangAn-Shoei Yang
Feb 26, 2008·Psychiatry Research·Yen Kuang YangRu Band Lu
Aug 1, 2008·Medical Engineering & Physics·Wen-Hsien HsuChing-Chi Hsu
Apr 17, 2009·Dental Materials : Official Publication of the Academy of Dental Materials·Chun-Li LinYi-Feng Lin
Jan 12, 2010·Clinical Neurology and Neurosurgery·Andre C FelicioHenrique B Ferraz
Jan 26, 2010·Journal of the Neurological Sciences·Andre C FelicioHenrique B Ferraz
May 25, 2010·Psychopharmacology·Andre C FelicioRodrigo A Bressan
Feb 3, 2011·European Journal of Nuclear Medicine and Molecular Imaging·Walter KochGabriele Pöpperl
Feb 10, 2011·The Journal of Neuropsychiatry and Clinical Neurosciences·Hao WuGuohua Shi
Jul 26, 2011·Journal of the Neurological Sciences·Tais S MoriyamaRodrigo A Bressan
May 12, 2012·Parkinsonism & Related Disorders·Pedro Braga-NetoOrlando Graziani Povoas Barsottini
Citations
Feb 8, 2020·Annals of Nuclear Medicine·Yu SunXingdang Liu
Mar 8, 2019·Annals of Nuclear Medicine·Taise VitorAndre C Felicio
Jul 22, 2018·Neural Regeneration Research·Ling LinZhi-Hong Zheng