Optimization of Insulin Regimen and Glucose Outcomes with Short-Term Real-Time Continuous Glucose Monitoring in Adult Type 1 Diabetes Patients with Suboptimal Control on Multiple Daily Injections: The Adult DIACCOR Study

Diabetes Technology & Therapeutics
Sylvie PicardBruno Guerci

Abstract

The impact of a 7-day real-time continuous glucose monitoring (RT-CGM) on type 1 diabetes (T1D) management remains unclear in patients suboptimally controlled by multiple daily injections (MDI). The DIACCOR Study aimed to describe treatment decisions and glucose outcomes after a short-term RT-CGM sequence. This French multicenter longitudinal observational study included T1D patients with HbA1c >7.5% or history of severe hypoglycemia (SH) or recurrent documented hypoglycemia. A sensor was inserted at the inclusion visit, treatment changes were proposed by the investigator within 7-15 days ("INT" = MDI intensification, "CSII" = switch to continuous insulin infusion, or "ER" = educational reinforcement with no change in insulin regimen), and a 4-month follow-up visit (M4) was scheduled. Four hundred fifty-nine patients were recruited by 155 diabetologists, 17.0% had SH history, and 24.2% had recurrent hypoglycemia. Baseline HbA1c was 8.34% ± 1.21% (>7.5% in 79.6%). Overall, 253 (64.4%), 64 (16.3%), and 76 patients (19.3%) were, respectively, included in the "INT," "CSII," and "ER" subgroups. The number of patients who experienced SH or recurrent hypoglycemia dropped dramatically (7.9% vs. 17.0% and 10.8% vs. 24.2%, respectively)....Continue Reading

References

Jan 7, 2004·Diabetes & Metabolism·P Schaepelynck-BélicarV Lassmann-Vague
Oct 27, 2006·Diabetes Care·Jamie R WoodLori M B Laffel
Jul 1, 2008·Journal of Diabetes Science and Technology·Christophe De BlockLuc Van Gaal
Jan 16, 2010·Diabetes & Metabolism·V Lassmann-VagueUNKNOWN Société francophone du diabète (ex ALFEDIAM)
Jan 20, 2010·Diabetes Technology & Therapeutics·Sabine SeereinerThomas R Pieber
Jul 1, 2010·The New England Journal of Medicine·Richard M BergenstalUNKNOWN STAR 3 Study Group
Feb 8, 2011·Diabetic Medicine : a Journal of the British Diabetic Association·J HermanidesJ H DeVries
Jun 14, 2012·Diabetes Technology & Therapeutics·Gary M PepperKathryn Reynolds
Oct 16, 2012·Journal of Diabetes Science and Technology·Baraka FloydGuillermo E Umpierrez
Jun 22, 2013·Diabetes Technology & Therapeutics·Matthew LeinungShannon Thompson
Dec 21, 2013·Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición·Panagiota PapargyriJosé Manuel Miralles García
Jul 12, 2014·Diabetes Care·Jenise C WongUNKNOWN T1D Exchange Clinic Network
Sep 11, 2014·Diabetes·UNKNOWN Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) Research GroDavid M Nathan
Jan 7, 2015·JAMA : the Journal of the American Medical Association·UNKNOWN Writing Group for the DCCT/EDIC Research GroupJohn M Lachin
Feb 11, 2016·Diabetes Care·UNKNOWN Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) Study Resear
Apr 22, 2016·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Dalit GoldsteinAvraham Karasik
Jul 13, 2016·Journal of Diabetes Science and Technology·Sanjeev N MehtaMartin Ridderstråle
Sep 7, 2016·Journal of Diabetes Science and Technology·Jenise C WongUNKNOWN T1D Exchange Clinic Network
Dec 23, 2016·Current Medical Research and Opinion·William V TamborlaneMichelle Van Name
Jan 25, 2017·JAMA : the Journal of the American Medical Association·Roy W BeckUNKNOWN DIAMOND Study Group
May 28, 2017·Diabetes Care·Rose A Gubitosi-KlugUNKNOWN Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) Research Gro
Jun 7, 2017·Diabetes Technology & Therapeutics·Janet B McGill, Andrew Ahmann
Jul 28, 2017·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·Werner KernBernhard Kulzer

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Citations

Feb 18, 2020·Journal of Diabetes Science and Technology·Ralph ZieglerBernd Kulzer

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GECEM
DIACCOR

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