Optimization of iontophoretic parameters for the transdermal delivery of methotrexate

Drug Delivery
Viswatej VemulapalliPhillip M Friden

Abstract

The aim of this work was to study the in vitro factors affecting transdermal iontophoretic delivery of methotrexate across hairless rat skin. Initial screening studies evaluated the effect of ionic strength and donor concentration. A response surface model using factorial design shows an increase in the cumulative amount of methotrexate delivered (Y1) with an increase in current density (X1) and time of application (X2). However, 10 min iontophoresis and 0.05 mA/cm2 current density did not show an increase in delivery with an increase in current density or time of application, respectively. The factorial design was able to identify the optimal parameters that would have been difficult to predict with a conventional one at a time-experimental approach.

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Citations

Mar 4, 2011·AAPS PharmSciTech·Haripriya Kalluri, Ajay K Banga
Jul 22, 2010·Expert Opinion on Drug Delivery·Amitava Mitra, Yunhui Wu
Jun 21, 2012·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Fan YangMasahiro Goto
May 20, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Franciska ErdőYukio Kato
Aug 8, 2018·Pharmaceutics·Hiep X Nguyen, Ajay K Banga
Dec 10, 2013·The Journal of Biological Chemistry·Susumu HamaKentaro Kogure
Jan 17, 2020·The Australasian Journal of Dermatology·Naveen Kumar Andanooru ChandrappaSuresh Mahadevarahalli Rangegowda
Dec 14, 2011·Expert Opinion on Drug Delivery·Maria Begoña Delgado-Charro
Nov 17, 2020·International Journal of Pharmaceutics·Sonalika A BhattaccharjeeAjay K Banga
Sep 9, 2020·International Journal of Pharmaceutics·Madhura KaleAjay K Banga
Jun 26, 2021·International Journal of Pharmaceutics·Xiaoyuan YangYuehong Xu

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