Optimization of large-scale culture conditions for the production of cordycepin with Cordyceps militaris by liquid static culture

TheScientificWorldJournal
Chao KangKevin David Hyde

Abstract

Cordycepin is one of the most important bioactive compounds produced by species of Cordyceps sensu lato, but it is hard to produce large amounts of this substance in industrial production. In this work, single factor design, Plackett-Burman design, and central composite design were employed to establish the key factors and identify optimal culture conditions which improved cordycepin production. Using these culture conditions, a maximum production of cordycepin was 2008.48 mg/L for 700 mL working volume in the 1000 mL glass jars and total content of cordycepin reached 1405.94 mg/bottle. This method provides an effective way for increasing the cordycepin production at a large scale. The strategies used in this study could have a wide application in other fermentation processes.

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Citations

Feb 18, 2018·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Shuang YangJingsheng Liu
Feb 13, 2019·The Journal of General and Applied Microbiology·Jia-Fu HuangYu-Tian Pan
Jan 17, 2019·Applied Microbiology and Biotechnology·Phongsakorn KunhormParinya Noisa
Mar 21, 2020·International Journal of Environmental Research and Public Health·Xuanjiang YangQiang Zhang

Related Concepts

Cordycepin
Deoxyadenosines
Fermentation
Industrial Microbiology
Fermentors
Cordyceps sinensis (fungus)
Fermentation
Cordycepin
Laboratory Culture
Sampling Design

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