Optimization of multifocal transcranial current stimulation for weighted cortical pattern targeting from realistic modeling of electric fields

NeuroImage
Giulio RuffiniAlvaro Pascual-Leone

Abstract

Recently, multifocal transcranial current stimulation (tCS) devices using several relatively small electrodes have been used to achieve more focal stimulation of specific cortical targets. However, it is becoming increasingly recognized that many behavioral manifestations of neurological and psychiatric disease are not solely the result of abnormality in one isolated brain region but represent alterations in brain networks. In this paper we describe a method for optimizing the configuration of multifocal tCS for stimulation of brain networks, represented by spatially extended cortical targets. We show how, based on fMRI, PET, EEG or other data specifying a target map on the cortical surface for excitatory, inhibitory or neutral stimulation and a constraint on the maximal number of electrodes, a solution can be produced with the optimal currents and locations of the electrodes. The method described here relies on a fast calculation of multifocal tCS electric fields (including components normal and tangential to the cortical boundaries) using a five layer finite element model of a realistic head. Based on the hypothesis that the effects of current stimulation are to first order due to the interaction of electric fields with popul...Continue Reading

Associated Clinical Trials

Mar 5, 2021·Alvaro Pascual-Leone
Mar 5, 2021·Alvaro Pascual-Leone

References

Oct 1, 1986·IEEE Transactions on Bio-medical Engineering·F Rattay
Feb 24, 2004·The Journal of Physiology·Marom BiksonJohn G R Jefferys
Apr 15, 2004·Human Brain Mapping·Peter T FoxJack L Lancaster
Jun 26, 2004·Science·György Buzsáki, Andreas Draguhn
Mar 8, 2005·Neuron·Helen S MaybergSidney H Kennedy
Jun 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Michael D FoxMarcus E Raichle
Mar 18, 2006·Bipolar Disorders·Felipe FregniAlvaro Pascual-Leone
Nov 23, 2006·Nature Neuroscience·David RobbeGyörgy Buzsaki
Jan 26, 2007·Journal of Neurophysiology·M A NitscheW Paulus
Dec 26, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Daniella TerneyWalter Paulus
Mar 17, 2009·Journal of Affective Disorders·R FerrucciA Priori
Apr 3, 2009·The Journal of Clinical Investigation·Helen S Mayberg
Jul 2, 2010·Frontiers in Systems Neuroscience·Michael D Fox, Michael Greicius
Jul 14, 2010·Neuron·Flavio Fröhlich, David A McCormick
Nov 30, 2010·Disability and Rehabilitation·Hooman MahmoudiFelipe Fregni
Jun 11, 2011·Journal of Neural Engineering·Jacek P DmochowskiLucas C Parra
Aug 9, 2011·Neuropsychological Rehabilitation·Walter Paulus
Jan 5, 2012·The British Journal of Psychiatry : the Journal of Mental Science·Colleen K LooPerminder Sachdev
Mar 21, 2012·The European Journal of Neuroscience·Mouhsin M ShafiAlvaro Pascual-Leone
Sep 6, 2012·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·Giulio RuffiniPedro C Miranda
Oct 23, 2012·Frontiers in Psychiatry·Rosalind J SadleirBarry Gordon
Jan 1, 2013·NeuroImage·Pedro Cavaleiro MirandaGiulio Ruffini
Mar 13, 2013·The Journal of Physiology·Asif RahmanMarom Bikson
Jun 21, 2013·Frontiers in Human Neuroscience·Christoph S HerrmannDaniel Strüber
Jun 27, 2013·Nature Neuroscience·Randy L BucknerB T Thomas Yeo
Jun 27, 2013·Nature Neuroscience·Eran DayanLeonardo G Cohen
Jul 5, 2013·Frontiers in Human Neuroscience·Andrea Antal, Walter Paulus

❮ Previous
Next ❯

Citations

Oct 1, 2014·Proceedings of the National Academy of Sciences of the United States of America·Michael D FoxAlvaro Pascual-Leone
Dec 15, 2015·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·A J WoodsM A Nitsche
Jun 24, 2015·Neuropsychologia·Yong-Il ShinMichael A Nitsche
Jun 5, 2015·Frontiers in Neuroscience·Reiko MatsushitaRobert J Zatorre
Feb 7, 2015·Neuropsychologia·Yong-Il ShinMichael A Nitsche
Feb 24, 2015·Frontiers in Human Neuroscience·Padideh NasseriHamed Ekhtiari
Sep 2, 2014·Frontiers in Psychiatry·Michael RussellBruce G Lyeth
May 24, 2016·NeuroImage·Benjamin B RiskDavid Ruppert
May 21, 2016·Annals of the New York Academy of Sciences·Roberta SellaroLorenza S Colzato
Jun 16, 2016·Frontiers in Psychiatry·Mariano Fernández-CorazzaDon Tucker
May 25, 2016·Annals of Neurology·Rachel WurzmanMichael D Fox
Jun 7, 2017·Annals of Neurology·Andreas HornMichael D Fox
Feb 14, 2018·Movement Disorders : Official Journal of the Movement Disorder Society·Moria DaganJeffrey M Hausdorff
Feb 2, 2018·Journal of Neural Engineering·Sofia R FernandesPedro C Miranda
Dec 29, 2017·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Estelle Raffin, Friedhelm C Hummel
Aug 11, 2018·The Journal of ECT·Dennis Q Truong, Marom Bikson
Feb 7, 2019·Journal of Neurophysiology·Andreas FellnerFrank Rattay
Jan 4, 2019·Journal of Neural Engineering·Aprinda IndahlastariRosalind J Sadleir
Feb 8, 2019·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Yuranny Cabral-Calderin, Melanie Wilke
Oct 25, 2016·Journal of the International Neuropsychological Society : JINS·Michael DoppelmayrFabian Steinberg
Jul 9, 2014·Physics in Medicine and Biology·Pedro C MirandaPeter J Basser
Jun 17, 2020·Annals of Neurology·Yan SunAlexander Rotenberg
Feb 18, 2017·Dose-response : a Publication of International Hormesis Society·James GiordanoEdward Calabrese
Jun 10, 2017·Der Nervenarzt·A Stockert, D Saur

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Visualized Experiments : JoVE
Pedro SchestatskyF Fregni
Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Mohamed K MetwallyTae-Seong Kim
IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society
Giulio RuffiniPedro Cavaleiro Miranda
© 2021 Meta ULC. All rights reserved