Optimization of nutrition during allogeneic hematologic stem cell transplantation

Current Opinion in Clinical Nutrition and Metabolic Care
Annic BaumgartnerPhilipp Schuetz

Abstract

Malnutrition before and during hematopoietic stem cell transplantation (HSCT) is an independent risk factor for mortality in patients undergoing hematopoietic stem cell transplantation. Yet, optimal use of nutritional support to improve outcomes remains controversial. Our aim was to do an up-to-date literature review regarding nutritional therapy in allogeneic HSCT, the neutropenic diet and the use of immunonutrients. Several observational studies find malnutrition to be associated with poor outcome, increased complications and lower overall survival. There are, however, few interventional trials proving the benefits of nutritional therapy in this population compared with no nutritional treatment. Regarding routes of treatment, studies suggested that parenteral nutrition is associated with higher risk for complications compared with enteral nutrition. Whether the use of specific formulas, such as immunonutrition, has a beneficial effect on clinical outcome is not established yet. Strict use of neutropenic diets did not show a reduction in infection risk and clinical outcome, and can no longer be recommended. Our updated search confirms that malnutrition is a strong negative predictor for outcome, yet optimal use of nutritional ...Continue Reading

References

Aug 14, 2013·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Romain GuièzeCorinne Bouteloup
Jul 6, 2014·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Sarah AndersenMerrilyn Banks
Mar 24, 2015·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·T CederholmP Singer
Jun 11, 2015·International Journal of Cancer. Journal International Du Cancer·Joachim WiskemannMartin Bohus
Jul 15, 2015·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Shigeo FujiMarkus Kapp
Aug 20, 2015·Beneficial Microbes·V Stadlbauer
Sep 25, 2015·Nutrition and Cancer·Mohamad Bassam SonbolThomas E Witzig
Jan 19, 2016·Current Hematologic Malignancy Reports·Tessa M AndermannAmi S Bhatt
Jun 9, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lars TramsenThomas Lehrnbecher
Jun 28, 2016·Bone Marrow Transplantation·D ZamaA Pession

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Citations

Jun 20, 2018·Current Opinion in Clinical Nutrition and Metabolic Care·Emanuele CeredaRiccardo Caccialanza
Jan 10, 2020·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Rianne van LieshoutSandra Beijer

Jan 5, 2021·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
Aug 28, 2019·Clinical Nutrition ESPEN·Erika Yuri HiroseCelso Arrais-Rodrigues

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