Optimization of process parameters in preparation of tocotrienol-rich red palm oil-based nanoemulsion stabilized by Tween80-Span 80 using response surface methodology

PloS One
Wai-Ting ChongOi-Ming Lai

Abstract

Red palm oil (RPO) is a natural source of Vitamin E (70-80% tocotrienol). It is a potent natural antioxidant that can be used in skin-care products. Its antioxidant property protects skin from inflammation and aging. In our work, a tocotrienol-rich RPO-based nanoemulsion formulation was optimized using response surface methodology (RSM) and formulated using high pressure homogenizer. Effect of the concentration of three independent variables [surfactant (5-15 wt%), co-solvent (10-30 wt%) and homogenization pressure (500-700 bar)] toward two response variables (droplet size, polydispersity index) was studied using central composite design (CCD) coupled to RSM. RSM analysis showed that the experimental data could be fitted into a second-order polynomial model and the coefficients of multiple determination (R2) is 0.9115. The optimized formulation of RPO-based nanoemulsion consisted of 6.09 wt% mixed surfactant [Tween 80/Span 80 (63:37, wt)], 20 wt% glycerol as a co-solvent via homogenization pressure (500 bar). The optimized tocotrienol-rich RPO-based nanoemulsion response values for droplet size and polydispersity index were 119.49nm and 0.286, respectively. The actual values of the formulated nanoemulsion were in good agreement...Continue Reading

References

Aug 1, 1997·Journal of Colloid and Interface Science·S Mohan, G Narsimhan
May 23, 2001·Journal of Agricultural and Food Chemistry·N GartiH J Watzke
Sep 22, 2001·The American Journal of Clinical Nutrition·G LietzA Tomkins
Apr 17, 2002·International Journal of Pharmaceutics·Lara O Orafidiya, F A Oladimeji
Mar 24, 2004·Micron : the International Research and Review Journal for Microscopy·M G Kosmadaki, B A Gilchrest
Apr 10, 2004·Advances in Colloid and Interface Science·Tharwat TadrosC Solans
Jul 22, 2004·International Journal of Pharmaceutics·K BouchemalH Fessi
Jul 28, 2004·Langmuir : the ACS Journal of Surfaces and Colloids·Paqui IzquierdoConxita Solans
Mar 31, 2005·Journal of Colloid and Interface Science·Paqui IzquierdoConxita Solans
Sep 1, 2005·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Cornelia M Keck, Rainer H Müller
May 21, 2008·Journal of Nutritional Science and Vitaminology·Yasushi YamadaKanae Yamashita
Sep 2, 2008·Talanta·Marcos Almeida BezerraLuciane Amélia Escaleira
Oct 15, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Tim J WoosterPeerasak Sanguansri
Nov 29, 2008·Journal of Colloid and Interface Science·Lijuan WangXuefeng Li
Nov 26, 2009·Journal of Nanoscience and Nanotechnology·Fernanda S PolettoAdriana R Pohlmann
Nov 28, 2009·Journal of Colloid and Interface Science·Björn Niemann, Kai Sundmacher
Dec 2, 2009·Journal of Colloid and Interface Science·Lidija B PetrovicJadranka L Milanovic
Dec 5, 2009·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Claudia PreetzKarsten Mäder
Jan 26, 2010·British Journal of Biomedical Science·O O OguntibejuE J Truter
Jun 19, 2010·International Journal of Pharmaceutics·Junya HatanakaShizuo Yamada
Feb 15, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Lena L HechtHeike P Schuchmann
Mar 25, 2011·Critical Reviews in Food Science and Nutrition·David Julian McClements, Jiajia Rao
Aug 26, 2014·Food Chemistry·Sara RebolledaMaría Luisa González San-José
Nov 26, 2015·International Journal of Analytical Chemistry·Hui-Ling CheJu-Yen Fu
Dec 27, 2015·Pharmacology & Therapeutics·Hong Yong PehW S Fred Wong
Oct 30, 2016·International Journal of Molecular Sciences·Puvaneswari Meganathan, Ju-Yen Fu
Dec 19, 2017·Advances in Colloid and Interface Science·David Julian McClements, Seid Mahdi Jafari

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Citations

Feb 20, 2019·Biomolecules·Danial Efendy GoonMusalmah Mazlan
May 6, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Jannatul FardousHiroyuki Ijima
Jul 19, 2021·Drug Delivery and Translational Research·Katayoun Morteza-SemnaniAli Nokhodchi
Aug 8, 2021·International Journal of Molecular Sciences·Jelena B ĐokovićSnežana D Savić

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