Optimization of Quercetin loaded Palm Oil Ester Based Nanoemulsion Formulation for Pulmonary Delivery

Journal of Oleo Science
Noor Hafizah ArbainMohd Basyaruddin Abdul Rahman

Abstract

In this research, the palm oil ester (POE)- based nanoemulsion formulation containing quercetin for pulmonary delivery was developed. The nanoemulsion formulation was prepared by high energy emulsification method and then further optimized using D-optimal mixture design. The concentration effects of the mixture of POE:ricinoleic acid (RC), ratio 1:1 (1.50-4.50 wt.%), lecithin (1.50-2.50 wt.%), Tween 80 (0.50-1.00 wt.%), glycerol (1.50-3.00 wt.%), and water (88.0-94.9 wt.%) towards the droplet size were investigated. The results showed that the optimum formulation with 1.50 wt.% POE:RC, 1.50 wt.% lecithin, 1.50 wt.% Tween 80, 1.50 wt.% glycerol and 93.90 % water was obtained. The droplet size, polydispersity index (PDI) and zeta potential of the optimized formulation were 110.3 nm, 0.290 and -37.7 mV, respectively. The formulation also exhibited good stability against storage at 4℃ for 90 days. In vitro aerosols delivery evaluation showed that the aerosols output, aerosols rate and median mass aerodynamic diameter of the optimized nanoemulsion were 99.31%, 0.19 g/min and 4.25 µm, respectively. The characterization of physical properties and efficiency for aerosols delivery results suggest that POE- based nanoemulsion containing ...Continue Reading

References

Nov 18, 2003·British Journal of Clinical Pharmacology·N R Labiris, M B Dolovich
Jan 18, 2006·Biochemistry·Matthew R SchaabWilson A Francisco
Oct 3, 2006·International Journal of Pharmaceutics·Abhijit A Date, M S Nagarsenker
Apr 25, 2007·International Journal of Pharmaceutics·Thu GhazanfariKevin M G Taylor
Aug 11, 2007·International Journal of Pharmaceutics·Tzu-Hui WuThau-Ming Cham
Oct 28, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·HouLi LiHongXiang Lou
Oct 29, 2008·Evidence-based Complementary and Alternative Medicine : ECAM·Deborah A KennedyDugald Seely
Apr 21, 2009·Colloids and Surfaces. B, Biointerfaces·Yan GaoGuangxi Zhai
Feb 25, 2010·Journal of Nanobiotechnology·Brian Sheng Xian TeoMohd Basyaruddin Abdul Rahman
Jul 31, 2012·International Journal of Pharmaceutics·Maha NasrAbdelbary Elhissi
Jan 22, 2013·Journal of Agricultural and Food Chemistry·Ayse KaradagQingrong Huang
Jan 25, 2013·Journal of Nanobiotechnology·Navin Kumar VermaYurii K Gun'ko
Aug 27, 2013·International Journal of Pharmaceutics·Mohammad NajlahAbdelbary Elhissi
Aug 27, 2013·Colloids and Surfaces. B, Biointerfaces·Siti Hajar MusaAhmad Fuad Shamsuddin
May 27, 2014·Expert Opinion on Drug Delivery·Wing-Hin LeeRamin Rohanizadeh
Jan 23, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ju-Suk NamSang-Soo Lee

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.