Optimization of supervised cluster analysis for extracting reference tissue input curves in (R)-[(11)C]PK11195 brain PET studies.

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Maqsood YaqubRonald Boellaard

Abstract

Performance of two supervised cluster analysis (SVCA) algorithms for extracting reference tissue curves was evaluated to improve quantification of dynamic (R)-[(11)C]PK11195 brain positron emission tomography (PET) studies. Reference tissues were extracted from images using both a manually defined cerebellum and SVCA algorithms based on either four (SVCA4) or six (SVCA6) kinetic classes. Data from controls, mild cognitive impairment patients, and patients with Alzheimer's disease were analyzed using various kinetic models including plasma input, the simplified reference tissue model (RPM) and RPM with vascular correction (RPMV(b)). In all subject groups, SVCA-based reference tissue curves showed lower blood volume fractions (V(b)) and volume of distributions than those based on cerebellum time-activity curve. Probably resulting from the presence of specific signal from the vessel walls that contains in normal condition a significant concentration of the 18 kDa translocation protein. Best contrast between subject groups was seen using SVCA4-based reference tissues as the result of a lower number of kinetic classes and the prior removal of extracerebral tissues. In addition, incorporation of V(b) in RPM improved both parametric i...Continue Reading

References

Apr 1, 1997·IEEE Transactions on Medical Imaging·M DefriseD F Newport
Apr 1, 1997·IEEE Transactions on Medical Imaging·F MaesP Suetens
Jul 1, 1997·Journal of Computer Assisted Tomography·J WestR P Woods
Dec 1, 1996·NeuroImage·A A Lammertsma, S P Hume
Feb 24, 2001·European Journal of Nuclear Medicine·R BoellaardA A Lammertsma
Aug 8, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R N GunnV J Cunningham
Aug 22, 2001·Lancet·A CagninR B Banati
Mar 4, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Marc A KrophollerAdriaan A Lammertsma
Jul 18, 2008·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Giampaolo TomasiFederico E Turkheimer
Dec 17, 2009·Movement Disorders : Official Journal of the Movement Disorder Society·Richard DodelKarla Eggert
Jan 15, 2010·Physics in Medicine and Biology·Katherine R GrayLula Rosso

❮ Previous
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Citations

Feb 26, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Andrea VarroneChrister Halldin
May 30, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Zhangjie SuRainer Hinz
Apr 7, 2015·Expert Opinion on Drug Discovery·Paul M Matthews, Gourab Datta
Jan 16, 2016·Journal of Viral Hepatitis·H PflugradK Weissenborn
Aug 8, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Yoko IkomaFederico E Turkheimer
Nov 6, 2014·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Eero RissanenJuha O Rinne
Nov 6, 2014·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Francesca ZanderigoRamin V Parsey
Feb 5, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Sandeep S V GollaJuha O Rinne
Jan 1, 2015·Clinical and Translational Imaging : Reviews in Nuclear Medicine and Molecular Imaging·Laura AirasJuha O Rinne
Jun 11, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Mattia VeroneseFederico E Turkheimer
Dec 3, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·James VarleyPaul Edison
Sep 10, 2014·IEEE Transactions on Image Processing : a Publication of the IEEE Signal Processing Society·Vincent JaouenClovis Tauber
Feb 15, 2015·Neurobiology of Aging·Sophie SérrièreSylvie Chalon
Nov 25, 2014·Brain : a Journal of Neurology·Paolo GiannettiPaola Piccini
Jul 7, 2016·Epilepsia·Tracy ButlerJacqueline French
Aug 3, 2016·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Sujata SridharanHervé Boutin
Jul 31, 2012·Neurobiology of Aging·Alie SchuitemakerBart N M van Berckel
Sep 8, 2016·NPJ Schizophrenia·Thalia F van der DoefBart N M van Berckel
Nov 6, 2010·Neurobiology of Aging·Alie SchuitemakerBart N M van Berckel
Oct 21, 2016·The British Journal of Psychiatry : the Journal of Mental Science·L SuJ T O'Brien
Feb 10, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Daniel García-LorenzoMichel Bottlaender
May 6, 2017·International Journal of Molecular Sciences·Chiara CeramiDaniela Perani
May 19, 2017·Journal of Neural Transmission·Julien LagardeMichel Bottlaender
Jun 28, 2017·Brain Research·Kerstin HeurlingMark Lubberink
Nov 15, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Gaia RizzoAlessandra Bertoldo
Dec 20, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Paul CummingRichard Banati
Nov 8, 2018·Brain : a Journal of Neurology·Ajenthan SurendranathanJohn T O'Brien
Oct 27, 2017·F1000Research·Leonardo IaccarinoDaniela Perani
Oct 30, 2015·Physics in Medicine and Biology·Roger N GunnJulie C Price
Jun 25, 2019·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Daniela PeraniUNKNOWN IMBI Project
Mar 10, 2018·Neurology. Neuroimmunology and Neuroinflammation·Eero RissanenLaura Airas
May 8, 2020·Brain : a Journal of Neurology·Maura MalpettiJames B Rowe
Sep 13, 2020·Journal of Neurology, Neurosurgery, and Psychiatry·Audrey LowJohn T O'Brien
Oct 3, 2020·Brain : a Journal of Neurology·Marcus SucksdorffLaura Airas
Nov 10, 2015·Biochemical Society Transactions·Federico E TurkheimerMattia Veronese
Mar 18, 2020·Brain : a Journal of Neurology·W Richard Bevan-JonesJames B Rowe
Aug 23, 2018·Frontiers in Neurology·Paul EdisonMagdalena Sastre
Jan 30, 2018·Annals of Clinical and Translational Neurology·Leonardo IaccarinoDaniela Perani

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Software Mentioned

SVCA6
SVCA4
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SVCA

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