PMID: 15381872Sep 24, 2004Paper

Optimization of technetium-99m Sestamibi single-photon emission tomography to define multidrug resistance with confidence

Nuclear Medicine Communications
Rachael E MoorinJ Harvey Turner

Abstract

The efflux rate of technetium-99m Sestamibi (99mTc-Sestamibi) is a kinetic phenomenon related to the response of cancer cells to chemotherapy, and may be used to determine drug resistance. Measurement of the efflux rate requires accurate quantitative single-photon emission tomography (SPET) imaging within the time constraints imposed by the kinetics of the process. A phantom study, at activity concentrations typically found with 99mTc-Sestamibi in vivo, was undertaken to optimize the SPET parameters and, in particular, to determine whether 180 degrees acquisition arcs with heads in 'L' configuration could be used for accurate quantification. Following the development of the most appropriate SPET protocol, a small patient pilot study was undertaken. Studies designed to evaluate statistical uncertainty (noise), contrast restitution and spatial resolution of the data sets, using different acquisition and reconstruction parameters, showed that 180 degrees SPET using a 64 x 64 matrix, 6 degrees angular sampling and iterative reconstruction was optimal. Finer linear and/or angular sampling afforded negligible improvement in resolution, but markedly increased the statistical uncertainty. Comparison of 360 degrees and 180 degrees acqui...Continue Reading

References

Jan 10, 1998·Nuclear Medicine Communications·C ScarfoneR E Coleman
May 20, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A CiarmielloM Salvatore
Oct 21, 2000·Cancer Biotherapy & Radiopharmaceuticals·S Del VecchioM Salvatore
Jun 5, 2002·Annals of Nuclear Medicine·Aysegul DirlikMustafa Ozhan
Jul 12, 2002·European Journal of Nuclear Medicine and Molecular Imaging·Mahmut YükselSakir Berkarda
Oct 1, 1994·Physics in Medicine and Biology·S R MeikleM J Fulham

❮ Previous
Next ❯

Citations

Jul 22, 2006·Annals of Nuclear Medicine·Aysegul AkgunZeynep Burak

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.