Optimization of temporal sampling for 82 rubidium PET myocardial blood flow quantification

Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
Benjamin C LeeVenkatesh L Murthy

Abstract

Suboptimal temporal sampling of left ventricular (LV) blood pool and tissue time-activity curves (TACs) may introduce bias and increased variability in estimates of myocardial blood flow (MBF) and flow reserve (MFR) from dynamic PET myocardial perfusion images. We aimed to optimize temporal sampling for estimation of MBF and MFR. Twenty-four normal volunteers and 32 patients underwent dynamic stress/rest rubidium-82 chloride (82Rb) PET imaging. Fine temporal sampling was used to estimate the full width at half maximum (FWHM) of the LV blood pool TAC. Fourier analysis was used to determine the longest sampling interval, T S, as a function of FWHM, which preserved the information content of the blood phase. Dynamic datasets were reconstructed with frame durations varying from 2 to 20 seconds over the first 2 minutes for the blood phase and 30 to 120 seconds for the tissue phase. The LV blood pool and tissue TACs were sampled using regions of interest (ROI) and fit to a compartment model for quantification of MBF and MFR. The effects of temporal sampling on MBF and MFR were evaluated using clinical data and simulations. T S increased linearly with input function FWHM (R = 0.93). Increasing the blood phase frame duration from 5 to ...Continue Reading

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Apr 15, 2015·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Jonathan B MoodyVenkatesh L Murthy

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Citations

Feb 23, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·S S KoendersJ A van Dalen
Sep 6, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Sami El-DalatiRichard L Weinberg
Apr 23, 2020·PloS One·Antoine GirardXavier Palard-Novello
Mar 25, 2018·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Benjamin C LeeVenkatesh L Murthy
Oct 28, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Alexis Poitrasson-Rivière, Venkatesh L Murthy
Jun 16, 2018·EJNMMI Research·Xavier Palard-NovelloHervé Saint-Jalmes
May 20, 2018·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Ian S Armstrong, Matthew J Memmott
Nov 9, 2018·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Benjamin C LeeEdward P Ficaro
Jun 27, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Sophia R LarsonRichard L Weinberg
Aug 8, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Ian S ArmstrongParthiban Arumugam
Mar 4, 2021·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·S S KoendersJ A van Dalen
Aug 28, 2021·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Alexis Poitrasson-RivièreEdward P Ficaro

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