PMID: 21780662Jul 26, 2011

Optimization of the control of blood pressure. What contribution can be obtained from use of combinations of fixed doses of ace inhibitors and calcium channel blockers?

Terapevticheskiĭ arkhiv
O M Eliseev


Basing on the results of large trials investigating efficacy of combined use of angiotensin-converting enzyme inhibitors (as a rule, perindopril) and calcium channel blockers (as a rule, amlodipin), the article analyses variety of mechanisms of their combined action, effects on dynamics of blood pressure, heart rate variability. The above combined treatment significantly reduces frequency of cardiovascular complications, improves the course of diabetes mellitus in its combination with arterial hypertension, renal function in patients with chronic renal failure and arterial hypertension. It is important to use fixed doses of the above drugs.

Related Concepts

Angiotensin-Converting Enzyme Inhibitors
Diastolic Blood Pressure
Calcium Channel Blockers
Dose-Response Relationship, Drug
Hypertensive Disease
Blood Pressure
Clinical Trials
Diabetes Mellitus
Kidney Failure, Chronic

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