Optimization of the differentiation and quantification of high-Z nanoparticles incorporated in medical devices for CT-guided interventions.

Medical Physics
Joy Vanessa D PerezMarites P Melancon

Abstract

Material differentiation has been made possible using dual-energy computed tomography (DECT), in which the unique, energy-dependent attenuating characteristics of materials can provide new diagnostic information. One promising application is the clinical integration of biodegradable polymers as temporary implantable medical devices impregnated with high-atomic number (high-Z) materials. The purpose of this study was to explore the incorporation of high atomic number (high-Z) contrast materials in a bioresorbable inferior vena cava filter for advanced CT-based monitoring of its location and differentiating from surrounding materials. Imaging optimization and calibration studies were performed using a body phantom. The dual-energy CT (DECT) ratios for iron, zirconium, barium, gadolinium, ytterbium, tantalum, tungsten, gold, and bismuth were generated for peak kilovoltage combinations of 80/150Sn, 90/150Sn, and 100/150Sn kVp in dual-source CT via linear regression of the CT numbers at low and high energies. A secondary calibration of the material map to the nominal material concentration was generated to correct for use of materials other than iodine. CT number was calibrated to the material concentration based on single-energy CT...Continue Reading

References

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Sep 22, 2020·Materialia·Joy Vanessa D PerezMarites Pasuelo Melancon
Jun 13, 2016·ACS Biomaterials Science & Engineering·Haoyan ZhouAgata Exner

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