Optimization of the radiosynthesis of the Alzheimer tracer 2-(4-N-[11C]methylaminophenyl)-6-hydroxybenzothiazole ([11C]PIB)

Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine
C PhilippeWolfgang Wadsak

Abstract

[(11)C]PIB is still the standard PET compound for Alzheimer imaging targeting beta-amyloid plaques. We aimed to establish a fully-automated procedure for the synthesis and purification of [(11)C]PIB with a high degree of reliability and improved specific activity as well as a suitable and fast quality control assay. The optimum reaction conditions were 75°C, 4 mg/mL precursor yielding at 48.0±2.7% (EOS, based on [(11)C]CH(3)OTf, corrected for decay), 183±14 GBq/μmol specific activity and >99% radiochemical purity. Time consumption was kept to a minimum (40 min from EOB) and overall yields were enough to serve 2 consecutive patients with a single preparation.

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Citations

Sep 17, 2014·The Journal of Nutrition, Health & Aging·P SaidlitzJ Delrieu
Aug 7, 2014·European Radiology·Liping FuJiahe Tian
Sep 4, 2012·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Johanna UngersboeckWolfgang Wadsak
Aug 8, 2015·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·A ColivaA Carpinelli
Jul 8, 2016·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·D H R StimsonR Bhalla
Oct 30, 2019·EJNMMI Radiopharmacy and Chemistry·Pablo BuccinoWilliams Porcal
Mar 14, 2018·Contrast Media & Molecular Imaging·Liping FuJiahe Tian
Jul 26, 2018·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Verena PichlerWolfgang Wadsak
Dec 3, 2020·Current Radiopharmaceuticals·Priya SaxenaFarogh Ahsan

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