Optimization of Ultrasonic-Assisted Simultaneous Extraction of Three Active Compounds from the Fruits of Forsythia suspensa and Comparison with Conventional Extraction Methods

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Xinsheng FangJianhua Wang

Abstract

An efficient ultrasonic-assisted extraction (UAE) method was developed for simultaneous extraction of three active compounds, forsythiaside A (FSA), phillyrin (PHI) and rutin (RT), from the fruits of Forsythia suspensa. The effects of various factors including a binary mixed solvent of methanol/water and ethanol/water, the pH of the solvent, particle size, temperature, solvent to material ratio, ultrasonic input power and extraction time on UAE were investigated in detail. The mass transfer mechanism of UAE using different mixed solvents was further explained by comparison with the maceration extraction method. The response surface methodology was used to optimize the experimental variables including ethanol concentration, solvent to material ratio and extraction time. The optimized conditions for the simultaneous extraction of RT, FSA and PHI were: particle size 60⁻80 mesh, temperature 30 °C, ultrasonic power 200 W, ethanol concentration 50%, solvent to material ratio 32 mL/g and extraction time 37 min. Compared to conventional extraction methods, UAE provided the highest extraction efficiency and offered many advantages including the reduction of solvent, temperature and time for extraction.

References

Mar 22, 2000·Biological & Pharmaceutical Bulletin·Y OzakiY T Tang
Nov 8, 2003·The Journal of Pharmacy and Pharmacology·J M PrietoJ L Ríos
Feb 3, 2005·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Toru Iizuka, Masahiro Nagai
Jun 21, 2006·Molecular and Cellular Biochemistry·N Kamalakkannan, P Stanely Mainzen Prince
Dec 29, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·T LuS W Kim
Aug 3, 2010·Phytotherapy Research : PTR·Huawei LiGuojuan Wu
Oct 29, 2010·Ultrasonics Sonochemistry·En-Qin XiaHua-Bin Li
Jan 11, 2011·Ultrasonics Sonochemistry·Farid ChematMuhammed Kamran Khan
Apr 20, 2011·European Journal of Pharmacology·Jong Min KimJong Hoon Ryu
Jan 8, 2013·Pharmacology, Biochemistry, and Behavior·Hong-Mei WangAhsana-Dar Farooq
Dec 30, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dong-Ping XuHua-Bin Li
Jun 22, 2016·Archives of Pharmacal Research·Xin-Yan QuSheng-Qi Wang
Feb 22, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tong ZhouHua-Bin Li

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Citations

May 28, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bancha YingngamAdelheid Brantner
Apr 5, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rui SongGuoqing Shen
Feb 17, 2021·Drug and Chemical Toxicology·Yinlu LiuBo Zhang
Oct 16, 2020·Critical Reviews in Food Science and Nutrition·Arakkaveettil Kabeer FarhaHarold Corke
Jun 7, 2021·International Journal of Biological Macromolecules·Jijuan NaiHuagang Sheng

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