Optimization of visual training for full recovery from severe amblyopia in adults

Learning & Memory
Nicolette C EatonElizabeth M Quinlan

Abstract

The severe amblyopia induced by chronic monocular deprivation is highly resistant to reversal in adulthood. Here we use a rodent model to show that recovery from deprivation amblyopia can be achieved in adults by a two-step sequence, involving enhancement of synaptic plasticity in the visual cortex by dark exposure followed immediately by visual training. The perceptual learning induced by visual training contributes to the recovery of vision and can be optimized to drive full recovery of visual acuity in severely amblyopic adults.

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Citations

Feb 22, 2018·The Journal of Comparative Neurology·Steven F GriecoXiangmin Xu
Dec 6, 2018·Journal of Neurophysiology·Abigail C GambrillHollis T Cline
Jun 16, 2018·Visual Neuroscience·Takao K Hensch, Elizabeth M Quinlan
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Jun 16, 2018·Visual Neuroscience·Michael P Stryker, Siegrid Löwel
Oct 13, 2017·The Journal of Comparative Neurology·Kevin R DuffyMark F Bear
Oct 1, 2019·Neural Plasticity·Alexander J LingleyKevin R Duffy

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