Optimized protocol for (18)F-choline PET/CT in patients with biochemically relapsed prostate cancer: experiences on 250 consecutive cases

Clinical Nuclear Medicine
Sotirios ChondrogiannisDomenico Rubello

Abstract

We review acquisition F-choline PET/CT methodology, evaluate a new F-choline acquisition protocol for prostate cancer (PC), and propose a standardized acquisition protocol on F-choline in PC patients. Two hundred fifty consecutive PC patients (mean age 72 years, mean PSA 7.9 ng/mL) were prospectively evaluated with F-choline PET/CT. An early scan of the pelvis (1 bed position of 4 minutes) was followed by a whole-body scan at 1 hour. Early and 1 delayed hour images of the pelvis were compared. Twenty-one percent of patients (n = 57) with positive F-choline demonstrated abnormal local uptake; 18% of patients (n = 45) showed distant localization only; 23% of patients (n = 53) had both local and distant localization; 38% of patients (n = 38) did not show any pathological uptake. All early images showed absence of radioactive urine in ureters, bladder, or urethra with satisfactory visualization of the prostatic region. Considering the group of patients with local uptake only, the prostatic region uptake, confirmed by late images, was better visualized in the early phase in 32/57 cases (SUVmax 12.4 ± 3.2 vs. 7.3 ± 5.2, P <0.01). Instead distant lesions were visualized on both early and late images with similar uptakes values (SUVmax...Continue Reading

References

Nov 30, 2005·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Martin HeinischWerner Langsteger
Jul 26, 2006·European Journal of Nuclear Medicine and Molecular Imaging·Marino CimitanMauro G Trovò
Sep 25, 2007·European Journal of Nuclear Medicine and Molecular Imaging·B J KrauseM Schwaiger
Oct 11, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Daniela B HusarikThomas F Hany
Feb 13, 2009·Nuklearmedizin. Nuclear Medicine·Ch SteinerF Buchegger
Aug 20, 2010·Journal of Medical Imaging and Radiation Oncology·J-M BeauregardR J Hicks
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman
Mar 11, 2011·Urologic Oncology·Bernd Joachim KrauseUwe Treiber
Mar 15, 2012·European Journal of Nuclear Medicine and Molecular Imaging·Jan D SoykaThomas F Hany
Oct 11, 2012·North American Journal of Medical Sciences·Arianna MassaroDomenico Rubello
Nov 28, 2012·Journal of Cancer Research and Clinical Oncology·Beatrice DettiGiampaolo Biti
Mar 15, 2013·Clinical Nuclear Medicine·Laura EvangelistaDomenico Rubello
Apr 6, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Mohsen BeheshtiWolfgang Loidl
Sep 28, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Ali Afshar-OromiehUwe Haberkorn
Dec 26, 2013·Clinical Nuclear Medicine·Ferdinando CalabriaOrazio Schillaci

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Citations

Nov 4, 2016·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Spencer C BehrMichael J Evans
Apr 15, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Giampiero GiovacchiniAndrea Ciarmiello
Jun 16, 2018·EJNMMI Research·Xavier Palard-NovelloHervé Saint-Jalmes

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