Optimized vs. Standard Automated Peritoneal Dialysis Regimens (OptiStAR): study protocol for a randomized controlled crossover trial

Pilot and Feasibility Studies
Karin BerglingCarl M Öberg

Abstract

It has been estimated that automated peritoneal dialysis (APD) is currently the fastest growing renal replacement therapy in the world. However, in light of the growing number of diabetic patients on peritoneal dialysis (PD), the unwanted glucose absorption during APD remains problematic. Recent results, using an extended 3-pore model of APD, indicated that large reductions in glucose absorption are possible by using optimized bi-modal treatment regimens, having "UF cycles" using a higher glucose concentration, and "Clearance cycles" using a low concentration or, preferentially, no glucose. The present study is designed to test the theoretical prediction of a lower glucose absorption using these novel regimes. This study is a randomized single-center, open-label, prospective study. Prevalent PD patients between 18 and 75 years old without known catheter problems or recent peritonitis are eligible for inclusion. Patients are allocated to a first treatment session of either standard APD (6 × 2 L 1.36% over 9 h) or optimized APD (7 × 2 L 2.27% + 5 × 2 L 0.1% over 8 h). A second treatment session using the other treatment will be performed in a crossover fashion. Samples of the dialysis fluid will be taken before and after the trea...Continue Reading

References

May 1, 1992·Kidney International·O HeimbürgerB Lindholm
Jul 28, 2001·Kidney International·K AteşA E Ertuğ
Apr 16, 2016·Seminars in Dialysis·Joanne M Bargman
Oct 25, 2016·Seminars in Dialysis·Bengt Rippe, Carl M Öberg
Dec 23, 2017·KI Reports·Carl M Öberg, Bengt Rippe
Feb 16, 2018·Clinical Journal of the American Society of Nephrology : CJASN·Sahir KalimJeffrey Perl
Feb 22, 2018·American Journal of Physiology. Renal Physiology·Julia DolininaCarl M Öberg
May 31, 2018·Journal of the American Society of Nephrology : JASN·Johann MorelleOlivier Devuyst
Jul 7, 2018·Journal of Nephrology·Silvio BorrelliUNKNOWN Study group Peritoneal Dialysis of Italian Society of Nephrology
Jun 27, 2019·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Cheng XueZhi-Guo Mao

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Citations

Apr 14, 2021·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Giedre MartusCarl M Öberg
Jan 18, 2022·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Karin BerglingCarl M Öberg

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Clinical Trials Mentioned

NCT04017572

Software Mentioned

HomeChoice Pro
OptiStAR

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