Optimizing 3D FLAIR to detect MS lesions: pushing past factory settings for precise results

Journal of Neurology
A LeclerJ Savatovsky

Abstract

To assess the diagnostic value of three 3D FLAIR sequences with differing repetition-times (TR) at 3-Tesla when detecting multiple sclerosis (MS) lesions. In this prospective study, approved by the institutional review board, 27 patients with confirmed MS were prospectively included. One radiologist performed manual segmentations of all high-signal intensity lesions using three 3D FLAIR data sets with different TR of 4800 ms ("FLAIR4800"), 8000 ms ("FLAIR8000") and 10,000 ms ("FLAIR10,000") and two radiologists double-checked it. The main judgment criterion was the overall number of lesions; secondary objectives were the assessment of lesion location, as well as measuring contrast-to-noise ratio (CNR) and signal-to-noise ratio (SNR). A non-parametric Wilcoxon's test was used to compare the differing FLAIR. The FLAIR8000 and FLAIR10,000 detected significantly more overall lesions per patient as compared with the FLAIR4800 [116.1 (± 61.7) (p = 0.02) and 115.8 (± 56.3) (p = 0.03) versus 99.2 (± 66.9), respectively]. The FLAIR8000 and FLAIR10,000 detected four and eight times more cortical or juxta-cortical lesions per patient as compared with FLAIR4800 [1.6 (± 2.2) (p = 0.001) and 4.1 (± 5.9) (p = 6 × 10-5) versus 0.4 (± 1.1), res...Continue Reading

References

Nov 1, 1984·AJR. American Journal of Roentgenology·V M RungeA E James
Dec 1, 1995·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J N RydbergC R Jack
Feb 28, 2007·Neurology·Istvan PirkoRohit Bakshi
May 30, 2008·European Radiology·Bastiaan MoraalFrederik Barkhof
Oct 28, 2008·Multiple Sclerosis : Clinical and Laboratory Research·F NelsonP A Narayana
Mar 24, 2010·Radiology·Bastiaan MoraalFrederik Barkhof
Feb 12, 2011·AJNR. American Journal of Neuroradiology·A MikeC R G Guttmann
Oct 8, 2011·Medical Physics·Frank L Goerner, Geoffrey D Clarke
Dec 6, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Paul PolakGuy Poloni
Nov 17, 2012·Lancet Neurology·Jeroen J G GeurtsRichard A Rudick
Jan 18, 2013·Prion·Roel KlaverJeroen J G Geurts
Mar 4, 2014·Multiple Sclerosis International·Silvia Messina, Francesco Patti
May 29, 2014·Acta Radiologica·Carolin GramschMarc Schlamann
Jul 15, 2015·Neuroscience·Caspar E P van MunsterJeroen J G Geurts
Oct 10, 2015·AJNR. American Journal of Neuroradiology·V WiggermannA Rauscher
Oct 29, 2015·Radiology·Patrick M BossuytUNKNOWN STARD Group
Nov 11, 2015·Multiple Sclerosis : Clinical and Laboratory Research·María I GaitánJorge Correale
Jan 30, 2016·Lancet Neurology·Massimo FilippiUNKNOWN MAGNIMS Study Group
Dec 26, 2017·Lancet Neurology·Alan J ThompsonJeffrey A Cohen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved