Optimizing a Male Reproductive Aging Mouse Model by D-Galactose Injection

International Journal of Molecular Sciences
Chun-Hou LiaoYing-Hung Lin

Abstract

The d-galactose (d-gal)-injected animal model, which is typically established by administering consecutive subcutaneous d-gal injections to animals for approximately six or eight weeks, has been frequently used for aging research. In addition, this animal model has been demonstrated to accelerate aging in the brain, kidneys, liver and blood cells. However, studies on aging in male reproductive organs that have used this animal model remain few. Therefore, the current study aimed to optimize a model of male reproductive aging by administering d-gal injections to male mice and to determine the possible mechanism expediting senescence processes during spermatogenesis. In this study, C57Bl/6 mice were randomized into five groups (each containing 8-10 mice according to the daily intraperitoneal injection of vehicle control or 100 or 200 mg/kg dosages of d-gal for a period of six or eight weeks). First, mice subjected to d-gal injections for six or eight weeks demonstrated considerably decreased superoxide dismutase activity in the serum and testis lysates compared to those in the control group. The lipid peroxidation in testis also increased in the d-gal-injected groups. Furthermore, the d-gal-injected groups exhibited a decreased r...Continue Reading

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Citations

Feb 7, 2017·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Malsawmhriatzuala JeremyVikas Kumar Roy
Aug 7, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Michael CurleyLee B Smith
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Sep 17, 2020··Rul Afiyah SyarifDicky Moch. Rizal

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Methods Mentioned

BETA
Assay
MDA
biopsies

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