Optimizing an algorithm for the identification and classification of pregnancy outcomes in German claims data

Pharmacoepidemiology and Drug Safety
Nadine WentzellRafael Mikolajczyk

Abstract

For studying drug utilization and safety in pregnancy based on administrative health care data, the reliable identification and classification of pregnancy outcomes in the data is essential. We aimed to optimize an existing algorithm for the identification and classification of pregnancy outcomes in the German Pharmacoepidemiological Research Database (GePaRD) with a particular focus on births. We reconsidered all codes used by the original algorithm and applied it to data of GePaRD from 2006 to 2014. Longitudinal records of pregnancies were used to identify targets for enhancing the algorithm's specificity. We checked the plausibility of the results, eg, regarding the age distribution of persons with pregnancy outcomes. Based on 20 longitudinal records of pregnancies, we compared the outcome classification by clinical experts with the results of the modified algorithm. Our algorithm identified 1 235 261 pregnancy outcomes in the database, with the majority (94%) being live births, classified as preterm (10%), term (78%), and (12%) births after the expected delivery date. The median age of pregnant women was 32 years (Q1 28; Q3 35). Implausible sequence of outcomes (for example, an induced abortion within a pregnancy categorize...Continue Reading

References

Dec 1, 1990·Geburtshilfe und Frauenheilkunde·P Berle, E Weiss
Feb 26, 2011·Pharmacoepidemiology and Drug Safety·Edeltraut GarbeUlrike Schmid
May 3, 2012·Pharmacoepidemiology and Drug Safety·Andrea V MargulisSonia Hernández-Díaz
Jun 5, 2013·Pharmacoepidemiology and Drug Safety·R T MikolajczykE Garbe
Jul 3, 2013·Pharmacoepidemiology and Drug Safety·Lucia Cea-SorianoSonia Hernández-Díaz
Mar 26, 2014·Pharmacoepidemiology and Drug Safety·Rachel A CharltonCorinne S de Vries
Jan 30, 2015·Pharmacoepidemiology and Drug Safety·Andrea V MargulisSonia Hernández-Díaz

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Citations

Jun 6, 2020·Pharmacoepidemiology and Drug Safety·Valeria BelleudiAntonio Addis
Apr 17, 2020·Schizophrenia Research·Johan ReutforsGabriella Bröms

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