Optimizing Antimicrobial Peptide Dendrimers in Chemical Space

Angewandte Chemie
Thissa N SiriwardenaJean-Louis Reymond

Abstract

We used nearest-neighbor searches in chemical space to improve the activity of the antimicrobial peptide dendrimer (AMPD) G3KL and identified dendrimer T7, which has an expanded activity range against Gram-negative pathogenic bacteria including Klebsiellae pneumoniae, increased serum stability, and promising activity in an in vivo infection model against a multidrug-resistant strain of Acinetobacter baumannii. Imaging, spectroscopic studies, and a structural model from molecular dynamics simulations suggest that T7 acts through membrane disruption. These experiments provide the first example of using virtual screening in the field of dendrimers and show that dendrimer size does not limit the activity of AMPDs.

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Citations

Mar 8, 2019·Molecular Informatics·Alice CapecchiJean-Louis Reymond
Mar 4, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Ksenia V KozhikhovaMusa R Khaitov
Feb 6, 2020·Antimicrobial Agents and Chemotherapy·Fatma Ben JeddouThilo Köhler
Aug 2, 2020·World Journal of Microbiology & Biotechnology·Songhita MukhopadhyayUsha Y Nayak
Sep 9, 2020·Chemical Communications : Chem Comm·Susanna J ZamoloJean-Louis Reymond
Jul 9, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Matthew DraytonSuzana K Straus
Dec 4, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bee-Ha GanJean-Louis Reymond
Jan 13, 2021·Journal of Cheminformatics·Alice CapecchiJean-Louis Reymond
Dec 24, 2019·Journal of Chemical Information and Modeling·Alice CapecchiJean-Louis Reymond
Jan 21, 2021·Pharmaceutics·Annarita FalangaStefania Galdiero
Dec 29, 2020·Medicinal Research Reviews·Fanwang MengCheng Luo
Mar 13, 2021·Chemical Society Reviews·Wenyi LiJohn D Wade
May 12, 2021·Chemical Communications : Chem Comm·Xingguang CaiJean-Louis Reymond
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Paris JafariThilo Köhler
Nov 24, 2019·International Journal of Pharmaceutics·Ana Paula DiasJeanine Giarolla
Aug 10, 2019·Bioconjugate Chemistry·Marc HeitzJean-Louis Reymond
Oct 17, 2019·ACS Infectious Diseases·Bee-Ha GanJean-Louis Reymond
Sep 27, 2019·Chemical Reviews·Rachit SapraV Haridas
Feb 4, 2021·ACS Central Science·Thissa N SiriwardenaJean-Louis Reymond
Mar 10, 2020·ACS Omega·Poonam SinglaDeepak B Salunke

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