Optimizing blood bank resources when implementing a low-titer group O+ whole blood program: an in silico study.

Transfusion
Jansen SeheultMark H Yazer

Abstract

Low-titer group O+ whole blood (LTOWB) is becoming commonly used in massive bleeding resuscitation, but the impact on blood center O+ RBCs has not been studied. This in silico model simulated a variety of different LTOWB production and utilization patterns. Collections and distributions data from a large blood collector were scaled to vary the total number of O+ red blood cell (RBC) collections, the O+ RBC collection: import ratio, and the O+ RBC apheresis: whole blood (WB) collection ratio. Daily LTOWB demand was determined by the daily number of LTOWB recipients, average number of LTOWB units transfused per patient, maximum number of LTOWB units a single patient can receive, and seasonality of LTOWB use. LTOWB program factors included the high-titer exclusion %, the LTOWB expiry, and whether LTOWB units were reclaimed as O+ RBC units on the date of expiry. Simulations using unique combinations of the above input parameters were performed. For the 1,224,720 unique combinations of input parameters simulated, the average increase in the fraction of additional O+ RBC units required to meet hospital demand was only 0.02%. Higher daily LTOWB demand resulted in more LTOWB shortages. Increasing the minimum LTOWB inventory threshold r...Continue Reading

References

May 7, 2016·Bioinformatics·Romain FenouilJean-Christophe Andrau
Jun 25, 2016·Transfusion·Mark H YazerUNKNOWN Biomedical Excellence for Safer Transfusions (BEST) Collaborative
Jun 8, 2017·Transfusion·Katherine D EllingsonSridhar V Basavaraju
Oct 27, 2017·JAMA : the Journal of the American Medical Association·Stacy A ShackelfordZsolt T Stockinger
Jul 26, 2018·The New England Journal of Medicine·Jason L SperryUNKNOWN PAMPer Study Group
Dec 15, 2018·Transfusion·Sarah K HarmUNKNOWN Biomedical Excellence for Safer Transfusion (BEST) Collaborative
Apr 14, 2019·Transfusion·Pampee P Young, P Dayand Borge

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Citations

Jun 2, 2020·Transfusion·David S MorrisDonald H Jenkins
Oct 1, 2020·Vox Sanguinis·Tor A HervigUNKNOWN Biomedical Excellence for Safer Transfusion Collaborative

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