Optimizing electroencephalographic studies for epilepsy diagnosis in children with new-onset seizures

Archives of Neurology
Lynette G Sadleir, Ingrid E Scheffer

Abstract

To establish whether early electroencephalography (EEG) or later sleep-deprived EEG (SD-EEG) has a higher yield of epileptiform and background abnormalities in children with new-onset seizures, and to use EEG results to assist in diagnosis of electroclinical epilepsy syndromes at presentation. Prospective analysis blinded to EEG protocol and epilepsy diagnosis. Regional service capturing a pediatric population of 121,000. Consecutive untreated children aged 2 to 16 years presenting to emergency departments with new-onset seizures (excluding myoclonic and absence seizures). Each child had 2 EEG protocols: an early EEG study (within 24 hours following a seizure) and an SD-EEG study (48 hours to 4 weeks following a seizure). Epilepsy diagnosis was made independently by 2 pediatric epileptologists. Rate of epileptiform abnormalities and slowing in the 2 EEG studies. The secondary outcome measure was diagnosis of epilepsy syndrome where possible. Of 92 children studied, 50 (54%) had a single seizure; 42 (46%) had 2 or more seizures at presentation. Seizures were focal in 61 children (66%) and generalized in 19 (21%). Epileptiform discharges occurred in 56 SD-EEGs (61%) and 52 early EEGs (57%) (P = .27). Background slowing occurred i...Continue Reading

Citations

Jan 10, 2012·Epilepsia·Danya F VearsIngrid E Scheffer
May 27, 2014·Brain & Development·Eli HeymanRevital Gandelman-Marton
Feb 19, 2020·Neurophysiologie clinique = Clinical neurophysiology·Walid AlesefirLouise Tyvaert

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