Optimizing Glycemic Control Through Titration of Insulin Glargine 100 U/mL: A Review of Current and Future Approaches with a Focus on Asian Populations

Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders
Chaicharn DeerochanawongMan Wo Tsang

Abstract

Various data have demonstrated inadequate glycemic control amongst Asians with type 2 diabetes mellitus (T2DM), possibly on account of suboptimal titration of basal insulin-an issue which needs to be further examined. Here we review the available global and Asia-specific data on titration of basal insulin, with a focus on the use of insulin glargine 100 U/mL (Gla-100). We also discuss clinical evidence on the efficacy and safety of titrating Gla-100, different approaches to titration, including some of the latest technological advancements, and guidance on the titration of basal insulin from international and local Asian guidelines. The authors also provide their recommendations for the initiation and titration of basal insulin for Asian populations. Discussion of the data included in this review and in relation to the authors' clinical experience with treating T2DM in Asian patients is also included. Briefly, clinical studies demonstrate the achievement of adequate glycemic control in adults with T2DM through titration of Gla-100. However, studies investigating approaches to titration, specifically in Asian populations, are lacking and need to be conducted. Given that the management of insulin therapy is a multidisciplinary te...Continue Reading

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Citations

Dec 7, 2018·Journal of Diabetes Investigation·Kai-Jen TienWayne Huey-Herng Sheu
May 10, 2019·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Jeffrey I MechanickGuillermo E Umpierrez
Feb 6, 2020·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Sunil M JainSuhas Erande
Jan 4, 2019·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Robyn K PollomRamón Ortiz Carrasquillo
Aug 11, 2020·Clinical Medicine Insights. Endocrinology and Diabetes·Chaicharn DeerochanawongPuntip Tantiwong

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