Optimizing growth hormone therapy in children

Hormone Research
Adda Grimberg, P Cohen

Abstract

Over 12 years' experience with recombinant human growth hormone (rhGH) treatment has created a powerful and safe therapeutic tool. However, to fully optimize the potential of GH therapy and to provide a guide for future GH research, several key issues must be addressed. These are the identification of specific patients or conditions for whom rhGH provides proven long-term benefit; an understanding of when treatment should be started and stopped; a determination of the best dose and regimen; establishment of the most accurate parameter in measuring success of the treatment plan; and recognition of the therapy's potential adverse effects and their relation to dosing. To date, approved pediatric indications for GH therapy are GH deficiency, chronic renal insufficiency and Turner syndrome. Long-term benefits for other indications have yet to be clearly demonstrated. Although starting GH therapy at the youngest possible age yields better results, the treatment endpoint remains controversial. Data so far has shown that daily injections are superior to thrice weekly dosing. Bedtime administration provides more physiologic GH profiles than morning injections. Subcutaneous administration of GH is as efficacious as intramuscular GH and b...Continue Reading

Citations

May 1, 1998·Zygote : the Biology of Gametes and Early Embryos·J P XuT Mori
Mar 29, 2013·The New England Journal of Medicine·David B Allen, Leona Cuttler
Dec 13, 2000·Proceedings of the National Academy of Sciences of the United States of America·E AhlbomS Ceccatelli
Mar 23, 2011·Pediatrics·Adda GrimbergVirginia A Stallings
Jun 30, 2000·Molecular Genetics and Metabolism·A Grimberg
Feb 4, 2005·The Journal of Pediatrics·Adda GrimbergAndrew J Cucchiara
Oct 12, 2020·Journal of Human Genetics·Yena LeeBeom Hee Lee

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