Optimizing human in vivo dosing and delivery of β-alanine supplements for muscle carnosine synthesis

Amino Acids
Trent StellingwerffChris Boesch

Abstract

Interest into the effects of carnosine on cellular metabolism is rapidly expanding. The first study to demonstrate in humans that chronic β-alanine (BA) supplementation (~3-6 g BA/day for ~4 weeks) can result in significantly augmented muscle carnosine concentrations (>50%) was only recently published. BA supplementation is potentially poised for application beyond the niche exercise and performance-enhancement field and into other more clinical populations. When examining all BA supplementation studies that directly measure muscle carnosine (n=8), there is a significant linear correlation between total grams of BA consumed (of daily intake ranges of 1.6-6.4 g BA/day) versus both the relative and absolute increases in muscle carnosine. Supporting this, a recent dose-response study demonstrated a large linear dependency (R2=0.921) based on the total grams of BA consumed over 8 weeks. The pre-supplementation baseline carnosine or individual subjects' body weight (from 65 to 90 kg) does not appear to impact on subsequent carnosine synthesis from BA consumption. Once muscle carnosine is augmented, the washout is very slow (~2%/week). Recently, a slow-release BA tablet supplement has been developed showing a smaller peak plasma BA c...Continue Reading

References

Jan 1, 1990·Comparative Biochemistry and Physiology. A, Comparative Physiology·R C HarrisE Hultman
May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·R KohenB N Ames
Jan 1, 1985·Journal of Applied Physiology·W S ParkhouseW K Ovalle
Jun 1, 1974·Journal of Applied Physiology·J BergströmE Vinnars
Oct 15, 1994·European Journal of Biochemistry·A Bakardjiev, K Bauer
Jul 1, 1996·Journal of Applied Physiology·E HultmanP L Greenhaff
Jan 1, 1992·Molecular Aspects of Medicine·P J QuinnV E Formazuyk
Feb 5, 2000·Equine Veterinary Journal. Supplement·M Dunnett, R C Harris
Dec 11, 2002·The Journal of Biological Chemistry·Michael TeufelTatiana Smirnova
Dec 6, 2005·International Journal of Sport Nutrition and Exercise Metabolism·Gulshanara BegumMichael Leveritt
Apr 20, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Robert A CrozierMark H Pausch
May 1, 2007·Experimental Physiology·David T Thwaites, Catriona M H Anderson
Jul 3, 2007·Diabetes·Sibylle SauerhöferMarcus Johannes Moeller
Sep 14, 2007·European Journal of Applied Physiology·Louise DeldicqueMarc Francaux
Jan 10, 2009·Journal of Applied Physiology·Audrey BaguetWim Derave
Jan 26, 2010·The Journal of Biological Chemistry·Jakub DrozakEmile Van Schaftingen
May 19, 2010·Medicine and Science in Sports and Exercise·Guilherme Giannini ArtioliAntonio Herbert Lancha
Jun 15, 2010·Neurochemistry International·K E TiedjeD F Weaver
Jul 31, 2010·Journal of Applied Physiology·Audrey BaguetWim Derave
Mar 15, 2011·Amino Acids·M A Tarnopolsky
Aug 19, 2011·Amino Acids·Trent StellingwerffChris Boesch
Dec 6, 2011·Amino Acids·Jacques DécombazTrent Stellingwerff
Dec 14, 2011·Journal of Sports Sciences·Stuart M Phillips, Luc J C Van Loon
Feb 14, 2012·Amino Acids·R C HarrisC Sale

❮ Previous
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Citations

Feb 14, 2012·Amino Acids·R C HarrisC Sale
Mar 13, 2013·Amino Acids·Craig SaleRoger C Harris
Jul 10, 2013·Journal of Agricultural and Food Chemistry·Oun Ki ChangJun-Sang Ham
Oct 6, 2012·The Journal of Biological Chemistry·Pingyang LiuJianyong Li
May 15, 2013·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Vitor de Salles PainelliGuilherme Giannini Artioli
Jul 31, 2012·PloS One·Mariele Castilho PansaniSergio A R Paiva
Dec 5, 2014·Current Opinion in Clinical Nutrition and Metabolic Care·Laura BlancquaertWim Derave
Feb 15, 2012·Medicine and Science in Sports and Exercise·Phillip M BellingerJames W Fell
Feb 27, 2013·Medicine and Science in Sports and Exercise·Sanne StegenWim Derave
Feb 9, 2016·Free Radical Biology & Medicine·G L CloseJ P Morton
Dec 12, 2012·Chemico-biological Interactions·Héctor Riveros-RosasRosario A Muñoz-Clares
Jul 25, 2015·Amino Acids·Jay R HoffmanDaniel S Moran
Nov 28, 2013·Journal of Strength and Conditioning Research·Phillip M Bellinger
Oct 29, 2014·Journal of the Science of Food and Agriculture·Monika LukasiewiczJan Niemiec
Jul 16, 2015·Journal of the International Society of Sports Nutrition·Eric T TrexlerJose Antonio
May 23, 2014·Journal of Korean Neurosurgical Society·Hui-Seung ParkDoh-Hee Kim
Jul 29, 2016·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Phillip M Bellinger, Clare L Minahan
Jul 20, 2016·Medicine and Science in Sports and Exercise·Phillip M Bellinger, Clare L Minahan
Jan 21, 2017·Medicine and Science in Sports and Exercise·Laura BlancquaertWim Derave
Oct 11, 2017·Medicine and Science in Sports and Exercise·Signe Refsgaard BechNikolai Baastrup Nordsborg
Feb 22, 2018·International Journal of Sport Nutrition and Exercise Metabolism·Peter PeelingLouise M Burke
Feb 2, 2017·American Journal of Physiology. Endocrinology and Metabolism·Colleen S DeanePhilip J Atherton
Oct 12, 2018·PloS One·Gabriel Motta Pinheiro BrisolaAlessandro Moura Zagatto
Sep 14, 2018·Amino Acids·Dmitry Spelnikov, Roger Charles Harris
Oct 19, 2013·Physiological Reviews·Alexander A BoldyrevWim Derave
Jan 27, 2018·Journal of Exercise Nutrition & Biochemistry·Raúl DomínguezFernando Mata-Ordóñez
May 2, 2018·Journal of the International Society of Sports Nutrition·José Luis Maté-MuñozRaúl Domínguez
Dec 20, 2018·Journal of the International Society of Sports Nutrition·Liam BeasleyJustin Roberts
Jan 18, 2017·Journal of the International Society of Sports Nutrition·Y Peter JungRichard B Kreider
Jan 10, 2018·Journal of the International Society of Sports Nutrition·Raúl DomínguezManuel Vicente Garnacho-Castaño
Sep 24, 2014·Pharmacological Reviews·Michael BaderRobson A Santos
May 31, 2019·Nutrición hospitalaria·Álvaro Huerta OjedaRafael Guisado-Barrilao
Sep 12, 2019·Frontiers in Nutrition·Pedro PerimBryan Saunders
Jul 12, 2016·Current Sports Medicine Reports·Susan Boegman, Christine E Dziedzic
Aug 17, 2021·AIMS Public Health·Paulina Januszko, Ewa Lange

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