Optimizing in vivo small animal Cerenkov luminescence imaging

Journal of Biomedical Optics
Antonello E Spinelli, Federico Boschi

Abstract

In vivo Cerenkov luminescence imaging is a rapidly growing molecular imaging research field based on the detection of Cerenkov radiation induced by beta particles when traveling though biological tissues. We investigated theoretically the possibility of enhancing the number of the detected Cerenkov photons in the near infrared (NIR) region of the spectrum. The analysis is based on applying a photon propagation diffusion model to Cerenkov photons in the tissue. Results show that despite the smaller number of Cerenkov photons in the NIR region, the fraction exiting the tissues is greater than in the visible range, and thus, a charge-coupled device detector optimized for the NIR range will allow to obtain a higher signal. The comparison was performed considering Cerenkov point sources located at different depths inside the animal. We concluded that the improvement can be up to 35% and is more significant when the Cerenkov source to be imaged is located deeper inside the animal.

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Citations

Oct 1, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Daniel L J ThorekJan Grimm
May 16, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Patrick T K ChinFijs W B van Leeuwen
Jan 4, 2015·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Antonello E Spinelli, Federico Boschi
Apr 28, 2016·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Antonello E Spinelli, Federico Boschi
Oct 16, 2016·Clinical and Translational Imaging : Reviews in Nuclear Medicine and Molecular Imaging·M R GrootendorstA Purushotham
Jul 18, 2019·Journal of Biomedical Optics·Nallely Jiménez-MancillaHéctor Mendoza-Nava
Oct 22, 2017·Journal of Biophotonics·Federico BoschiAntonello E Spinelli
Jan 29, 2016·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Masako ShimamotoAkihiro Kojima
Nov 20, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Kai ZhangHong Zhang
Jan 23, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Antonello E Spinelli, Federico Boschi

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