Optimizing outcomes from ovarian tissue cryopreservation and transplantation; activation versus preservation

Human Reproduction
Dror MeirowClaus Yding Andersen

Abstract

Ovarian tissue cryopreservation and transplantation (OTCP) is gaining increasing traction in the field of fertility preservation as a result of accumulated successes. We now have a decade of experience with the technique, with tens of live births and greater than 90% return of ovarian function in graft recipients. Recently, a novel method of OTCP has been described, termed in vitro activated OTCP which proposes significant changes to the standard protocol. This method aims to stimulate activation of dormant follicles within the grafts prior to transplantation and ensure that mature oocytes can be generated in the immediate short term after transplantation. By contrast, conventional OTCP seeks to maintain dormancy and thus preserve the follicle reserve in the graft with the aim of maximizing graft lifespan. This opinion paper will compare the two methods of OTCP, highlighting their respective advantages and disadvantages, and provide suggestions as to when to apply either one of these methods in a clinical setting.

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Citations

Sep 9, 2015·Human Reproduction·Kazuhiro KawamuraAaron J Hsueh
Aug 26, 2016·Journal of Ovarian Research·Raffaella FabbriRoberto Paradisi
Nov 23, 2018·Stem Cell Research & Therapy·Luciana Lamarão DamousEdmund C Baracat
Dec 15, 2018·Human Reproduction·Christiani A AmorimMarie-Madeleine Dolmans
Aug 8, 2020·Endocrine Reviews·Johanne GrosboisIsabelle Demeestere
Jun 24, 2017·Journal of Assisted Reproduction and Genetics·Vitaly A KushnirNorbert Gleicher
Aug 23, 2017·Expert Review of Hematology·Mahmoud SalamaPeter Mallmann
Nov 4, 2017·Journal of Assisted Reproduction and Genetics·Zohar GavishDror Meirow
Nov 1, 2018·Climacteric : the Journal of the International Menopause Society·X RuanA O Mueck
Mar 11, 2016·Reproductive Medicine and Biology·Lalitha Devi, Sandeep Goel
May 10, 2019·Clinical Medicine Insights. Reproductive Health·Michael von WolffFrank Nawroth
Aug 21, 2019·Frontiers in Endocrinology·Marie-Madeleine DolmansCatherine Vander Linden
May 8, 2020·International Journal of Molecular Sciences·Erica SilvestrisAngelo Virgilio Paradiso
Jan 4, 2018·Human Fertility : Journal of the British Fertility Society·Ephia YasminUNKNOWN British Fertility Society
Jul 5, 2018·Pediatric Blood & Cancer·Antoinette AnazodoTeresa K Woodruff
May 1, 2021·International Journal of Molecular Sciences·Kim Cat Tuyen Vo, Kazuhiro Kawamura
May 3, 2021·Fertility and Sterility·Marie-Madeleine DolmansClaus Yding Andersen
Jun 9, 2021·Journal of Assisted Reproduction and Genetics·Zexu Jiao, Orhan Bukulmez

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