Optimizing sampling device for the fecal immunochemical test increases colonoscopy yields in colorectal cancer screening

European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)
Yanqin HuangShu Zheng

Abstract

The fecal immunochemical test (FIT) that quantifies hemoglobin concentration is reported to be better than qualitative FIT and the reason for its superiority has not been interpreted. To evaluate and understand the superiority of quantitative FIT, a representative randomly selected population (n=2355) in Jiashan County, China, aged 40-74 years was invited for colorectal cancer screening in 2012. Three fecal samples were collected from each participant by one optimized and two common sampling devices, and then tested by both quantitative and qualitative FITs. Colonoscopy was provided independently to all participants. The performances of five featured screening strategies were compared. A total of 1020 participants were eligible. For screening advanced neoplasia, the positive predictive value (PPV) and the specificity of the strategy that tested one sample dissolved in an optimized device by quantitative FIT [PPV=40.8%, 95% confidence interval (CI): 27.1-54.6; specificity=96.8%, 95% CI: 95.7-98.0] were significantly improved over the strategy that tested one sample dissolved in the common device by qualitative FIT (PPV=14.1%, 95% CI: 8.2-19.9; specificity=87.9%, 95% CI: 85.8-89.9), whereas the sensitivity did not differ (39.2 an...Continue Reading

Citations

Apr 28, 2017·Journal of Primary Care & Community Health·Jeanette M DalyBarcey T Levy
Dec 27, 2017·International Journal of Cancer. Journal International Du Cancer·Anton GiesHermann Brenner
Nov 8, 2017·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Corrado R AsteriaLuigi Boccia

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