DOI: 10.1101/19007971Oct 2, 2019Paper

Optimizing the deployment of ultra-low volume and indoor residual spraying for dengue outbreak response

MedRxiv : the Preprint Server for Health Sciences
S. M. CavanyT. Alex Perkins


Recent years have seen rising incidence of dengue and large outbreaks of Zika and chikungunya, which are all caused by viruses transmitted by Aedes aegypti mosquitoes. In most settings, the primary intervention against Aedes-transmitted viruses is vector control, such as indoor, ultra-low volume (ULV) spraying. Targeted indoor residual spraying (TIRS) has the potential to more effectively impact Aedes-borne diseases, but its implementation requires careful planning and evaluation. The optimal time to deploy these interventions and their relative epidemiological effects are not well understood, however. We used an agent-based model of dengue virus transmission calibrated to data from Iquitos, Peru to assess the epidemiological effects of these interventions under differing strategies for deploying them. Specifically, we compared strategies where spray application was initiated when incidence rose above a threshold based on incidence in recent years to strategies where spraying occurred at the same time(s) each year. In the absence of spraying, the model predicted 361,000 infections [inter-quartile range (IQR): 347,000 - 383,000] in the period 2000-2010. The ULV strategy with the fewest median infections was spraying twice yearly...Continue Reading

Related Concepts

Related Feeds

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.


Babesiosis is caused by parasites of the genus babesia, which are transmitted in nature by the bite of an infected tick. Discover the latest research on babesiosis here.

Related Papers

Le Journal médical libanais. The Lebanese medical journal
The Lancet Infectious Diseases
Raphael N'Guessan, Mark Rowland
European Journal of Anaesthesiology
O Pratt, A Vohra
© 2021 Meta ULC. All rights reserved