PMID: 2506153Apr 1, 1989Paper

Optimizing the immunohistochemical signal from the transferrin receptor in liver tissue

The Histochemical Journal
M LombardJ Crowe

Abstract

Cellular expression of the transferrin receptor is determined by the proliferative state and iron requirements of the cell. Previous immunohistochemical studies using a number of anti-(transferrin receptor) monoclonal antibodies confirmed the biochemical evidence that hepatocytes express the receptor, although the distribution shown was patchy with only a small number of cells showing positive staining. In the present study, a number of techniques have been compared to optimize detection of the immunohistochemical signal from the transferrin receptor in human liver tissue. Using an alkaline phosphatase detection system, widespread expression of this receptor with both cytoplasmic and membrane staining was found in all parenchymal and non-parenchymal cells.

References

Sep 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A B Bomford, H N Munro
Aug 1, 1986·Experimental Cell Research·M TavassoliK Harjes
Sep 1, 1987·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R SciotV J Desmet
Mar 1, 1973·The Journal of Clinical Investigation·B M BabiorJ T Curnutte
Mar 1, 1981·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S P Young, P Aisen
Jul 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·R SutherlandM Greaves
May 1, 1983·Journal of Clinical Pathology·K C GatterD Y Mason
Jan 1, 1981·Journal of Immunological Methods·G D Johnson, G M Nogueira Araujo

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