Optimizing the management of neuromyelitis optica and spectrum disorders in resource poor settings: Experience from the Mangalore demyelinating disease registry

Annals of Indian Academy of Neurology
Lekha PanditRakshith Shetty

Abstract

In resource-poor settings, the management of neuromyelitis optica (NMO) and NMO spectrum (NMOS) disorders is limited because of delayed diagnosis and financial constraints. To device a cost-effective strategy for the management of NMO and related disorders in India. A cost-effective and disease-specific protocol was used for evaluating the course and treatment outcome of 70 consecutive patients. Forty-five patients (65%) had a relapse from the onset and included NMO (n = 20), recurrent transverse myelitis (RTM; n = 10), and recurrent optic neuritis (ROPN; n = 15). In 38 (84.4%) patients presenting after multiple attacks, the diagnosis was made clinically. Only 7 patients with a relapsing course were seen at the onset and included ROPN (n = 5), NMO (n = 1), and RTM (n = 1). They had a second attack after a median interval of 1 ± 0.9 years, which was captured through our dedicated review process. Twenty-five patients had isolated longitudinally extensive transverse myelitis (LETM), of which 20 (80%) remained ambulant at follow-up of 3 ± 1.9 years. Twelve patients (17%) with median expanded disability status scale (EDSS) of 8.5 at entry had a fatal outcome. Serum NMO-IgG testing was done in selected patients, and it was positive i...Continue Reading

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Citations

Jan 17, 2015·Neurology India·Sharik Mustafa, Lekha Pandit
Apr 30, 2015·Multiple Sclerosis : Clinical and Laboratory Research·L PanditUNKNOWN GJCF International Clinical Consortium & Biorepository for Neuromyelitis Optica
Apr 8, 2014·The Neurohospitalist·Andrew Nathan Wilner
Nov 14, 2018·Journal of Neurology·Annette BaumgartnerOliver Stich
Jul 25, 2018·Multiple Sclerosis Journal - Experimental, Translational and Clinical·Lekha PanditKimhiko Kaneko
Aug 25, 2021·Indian Journal of Ophthalmology·Swati PhuljheleRohit Saxena

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