Optimizing the Readout of Lanthanide-DOTA Complexes for the Detection of Ligand-Bound Copper(I)

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Jill R HannaAlison N Hulme

Abstract

The CuAAC 'click' reaction was used to couple alkyne-functionalized lanthanide-DOTA complexes to a range of fluorescent antennae. Screening of the antenna components was aided by comparison of the luminescent output of the resultant sensors using data normalized to account for reaction conversion as assessed by IR. A maximum 82-fold enhanced signal:background luminescence output was achieved using a Eu(III)-DOTA complex coupled to a coumarin-azide, in a reaction which is specific to the presence of copper(I). This optimized complex provides a new lead design for lanthanide-DOTA complexes which can act as irreversible 'turn-on' catalytic sensors for the detection of ligand-bound copper(I).

References

Feb 1, 1996·Natural Product Reports·P G Sammes, G Yahioglu
Mar 26, 2003·Proceedings of the National Academy of Sciences of the United States of America·Joan Selverstone Valentine, P John Hart
Mar 20, 2004·Nature Reviews. Drug Discovery·Kevin J BarnhamAshley I Bush
Aug 28, 2004·Organic Letters·Timothy R ChanValery V Fokin
Sep 16, 2004·Bioconjugate Chemistry·Pinghua Ge, Paul R Selvin
Oct 13, 2005·Journal of the American Chemical Society·Kimberly E BeattyDavid A Tirrell
Jun 21, 2006·Dalton Transactions : an International Journal of Inorganic Chemistry·Simon J A Pope, Rebecca H Laye
Aug 31, 2006·Journal of the American Chemical Society·Romain F H Viguier, Alison N Hulme
Feb 3, 2007·Bioorganic & Medicinal Chemistry Letters·Clémentine FéauLuc Lebeau
Feb 6, 2007·Lancet·Aftab AlaMichael L Schilsky
May 24, 2007·Journal of the American Chemical Society·Matthew S TremblayDalibor Sames
Jul 5, 2007·Organic & Biomolecular Chemistry·K Eszter Borbas, James I Bruce
Dec 7, 2007·The Journal of Organic Chemistry·Anup M JawalekarFloris L van Delft
May 3, 2008·Journal of the American Chemical Society·Ying SongThomas J Meade
Feb 5, 2009·Accounts of Chemical Research·Craig P MontgomeryDavid Parker
Mar 28, 2009·Accounts of Chemical Research·Evan G MooreKenneth N Raymond
Aug 6, 2009·Dalton Transactions : an International Journal of Inorganic Chemistry·Maite JaureguiStephen Faulkner
Nov 4, 2009·Dalton Transactions : an International Journal of Inorganic Chemistry·Graeme J Stasiuk, Mark P Lowe
Apr 10, 2010·Journal of the American Chemical Society·Masayasu TakiYukio Yamamoto
Sep 30, 2010·Dalton Transactions : an International Journal of Inorganic Chemistry·Jonathan MartinelliRamon Vilar
Nov 30, 2010·Bioorganic & Medicinal Chemistry Letters·Mohd Aizuddin KamaruddinBim Graham
Mar 8, 2011·Chemical Society Reviews·Yu Heng LauMatthew H Todd
Mar 19, 2011·Journal of the American Chemical Society·Daniel J MastaroneThomas J Meade
May 10, 2011·Chemical Communications : Chem Comm·Mi Eun JunKyo Han Ahn
Sep 22, 2011·Journal of the American Chemical Society·Jing LiuNobuo Kimizuka
May 5, 2012·Angewandte Chemie·Chayasith UttamapinantAlice Y Ting
Oct 11, 2013·Organic & Biomolecular Chemistry·Anne I GermerothAlison N Hulme
Dec 18, 2013·Chemical Reviews·Marie C HeffernThomas J Meade
Dec 25, 2013·Beilstein Journal of Organic Chemistry·Regina Berg, Bernd F Straub
Dec 17, 2014·Lancet Neurology·Oliver BandmannStephen G Kaler
Feb 19, 2015·Chemical Society Reviews·Joseph A CotruvoChristopher J Chang
Mar 13, 2015·Nature Protocols·Yu Heng LauDavid R Spring
Jun 5, 2015·Chemistry : a European Journal·Harekrushna BeheraNandita Madhavan
Jul 29, 2015·Accounts of Chemical Research·Allegra T AronChristopher J Chang
Aug 19, 2015·Organic & Biomolecular Chemistry·Estela HaldónPedro J Pérez
Dec 15, 2015·Beilstein Journal of Organic Chemistry·Nicolas DesboisClaude P Gros
May 3, 2016·International Journal of Molecular Sciences·Eiichi Tokuda, Yoshiaki Furukawa
Jul 12, 2016·Metallomics : Integrated Biometal Science·M A GreenoughC M Opazo
Oct 27, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Li Li, Zhiyuan Zhang

❮ Previous
Next ❯

Citations

Nov 19, 2019·Chemical Communications : Chem Comm·Charmaine HeeK Swaminathan Iyer
Mar 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sebastiano Di PietroGiovanni Signore
Nov 1, 2018·Chemical Reviews·Thomas I Kostelnik, Chris Orvig
Dec 21, 2019·Inorganic Chemistry·Michèle ClercGilles Gasser
Aug 7, 2018·The Journal of Organic Chemistry·Bengt H Gless, Christian A Olsen
Dec 4, 2021·Frontiers in Chemistry·Birthe MeinekeSimon J Elsässer

❮ Previous
Next ❯

Methods Mentioned

BETA
NMR

Software Mentioned

Excel

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.