Optimum threshold setting for a positron-sensitive probe with background rejection capability

Annals of Nuclear Medicine
Seiichi YamamotoMichio Senda

Abstract

In a positron-sensitive probe composed of a plastic scintillator and a bismuth germanate (BGO), scattered annihilation photons in the plastic scintillator become background counts. Although these scattered annihilation photons can be rejected by higher threshold level settings for the scintillation pulse of the plastic scintillator and for that of the BGO, the system sensitivity is reduced. We have theoretically and experimentally optimized the threshold levels for both the plastic scintillator and the BGO. After calculating the energy loss in the plastic scintillator and the BGO for the scattered annihilation photons, we measured the background counts of a positron-sensitive probe by changing these threshold levels. Results revealed that one optimum threshold setting of the positron-sensitive probe was 0.3 of the peak level of the pulse for the plastic scintillator and 0.7 of that for the BGO. With these threshold levels, the background counts could be decreased to less than 0.2% of the true positron counts.

References

Feb 5, 1999·European Journal of Nuclear Medicine·A J Britten
Aug 7, 1999·European Journal of Nuclear Medicine·E J HoffmanJ S Iwanczyk
May 12, 2001·Clinical Positron Imaging : Official Journal of the Institute for Clinical P.E.T·D C. DesaiE W. Martin
Jul 17, 2001·Nuclear Medicine Communications·R J LedermanR L Wahl

❮ Previous
Next ❯

Citations

Mar 28, 2007·Annals of Nuclear Medicine·Seiichi YamamotoMichio Senda
Mar 18, 2005·Annals of Nuclear Medicine·Seiichi YamamotoMichio Senda
Apr 14, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Morand PiertMarkus Schwaiger
Apr 21, 2012·International Journal of Molecular Imaging·Ananth RaviCurtis B Caldwell
Oct 27, 2016·Medical Physics·Martin T KingLei Xing

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.