PMID: 9185312May 24, 1997Paper

Options for management of acute pain in the rat

The Veterinary Record
F V Abbott, M Bonder

Abstract

Clinical recommendations for analgesics in laboratory rodents are usually derived from basic research. However, animal models of pain often involve withdrawal reflexes evoked by threshold-level stimuli, whereas pain associated with surgery or disease involves injury and inflammation. Moreover, the analgesics used in research tend to be chosen as exemplars of a drug class, without regard for whether the route of administration is practical, whether the drug has useful kinetics or whether the side effects are tolerable. This paper provides data on the efficacy of drugs from four classes, using the formalin test as a model of injury-induced pain. Formalin (50 microliters, 2.5 per cent) was injected subcutaneously into a rat's paw and the behavioural response (lifting or licking of the paw) was recorded. Buprenorphine at 0.1 mg/kg and dipyrone at 200 mg/kg completely suppressed the pain responses. When formalin was injected six hours after buprenorphine or dipyrone, pain scores were 30 per cent of control scores. In the absence of pain and handling, 0.6 mg/kg buprenorphine was lethal to 25 per cent of rats. Locomotor activity was slightly depressed by 300 mg/kg dipyrone. Xylazine at 2 mg/kg suppressed pain responses, but the analge...Continue Reading

References

Aug 1, 1977·British Journal of Pharmacology·A CowanI R Macfarlane
Aug 1, 1977·British Journal of Pharmacology·A CowanE J Harry
Jul 1, 1992·International Endodontic Journal·P V Abbott
Oct 1, 1992·Pain·A TjølsenK Hole
Oct 1, 1991·Pharmacology, Biochemistry, and Behavior·M J Morgan, K B Franklin
Jan 1, 1990·Pharmacology, Biochemistry, and Behavior·K B FranklinS N Young
Feb 9, 1988·European Journal of Pharmacology·M Nakamura, S H Ferreira
Sep 1, 1988·Journal of Pharmacological Methods·C W MurrayA Cowan
Jul 15, 1986·European Journal of Pharmacology·F V AbbottB Connell
Dec 1, 1985·Toxicology and Applied Pharmacology·H H DonaubauerE Schütz
Apr 1, 1984·Laboratory Animals·P A Flecknell
Dec 14, 1984·Science·G W TermanJ C Liebeskind
Jan 1, 1980·Current Medical Research and Opinion·C V PatelG B Parulkar
Dec 1, 1982·Pharmacology, Biochemistry, and Behavior·F V AbbottB F Leber
Oct 1, 1980·British Journal of Clinical Pharmacology·J Gómez-JiménezR Olivares-Sosa
Apr 13, 1995·European Journal of Pharmacology·Y Hong, F V Abbott
Mar 1, 1995·Clinical Pharmacokinetics·M LevyB Rosenkranz
Oct 1, 1994·Journal of Pain and Symptom Management·R B PattS Reddy
Jan 14, 1994·European Journal of Pharmacology·C R Tonussi, S H Ferreira
Jan 1, 1994·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M RodríguezP Ortiz
Nov 1, 1993·The British Veterinary Journal·J H Liles, P A Flecknell
Jan 1, 1993·Anesthesia and Analgesia·C Stein
Mar 1, 1997·The Veterinary Journal·V MolonyM J Graham

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Citations

Aug 7, 2002·European Journal of Pharmacology·Annie-Kim Gilbert, Keith B J Franklin
Jun 23, 2000·Behavioural Brain Research·F V Abbott, K G Hellemans
Nov 15, 2002·Brain Research. Brain Research Protocols·K V ThrivikramanPaul M Plotsky
Aug 10, 2004·Clinical and Experimental Pharmacology & Physiology·Esmaeal Tamaddonfard, Saead Rahimi
Mar 6, 2009·Pakistan Journal of Biological Sciences : PJBS·A MojtahedinA Zanbouri
May 6, 2010·Indian Journal of Pharmacology·Ali MojtahedinAli Zanbouri
Jul 23, 2009·Journal of Pharmacological and Toxicological Methods·Luka PeternelManica Cerne
Aug 5, 2009·Phytotherapy Research : PTR·Esmaeal Tamaddonfard, Nasrin Hamzeh-Gooshchi
Feb 19, 2002·Neurobiology of Learning and Memory·Matthew R Holahan, Norman M White
Feb 15, 2001·Research in Veterinary Science·C Grant, R N Upton
Jan 15, 2004·American Journal of Physiology. Endocrinology and Metabolism·Robert A FrostCharles H Lang
Oct 22, 2005·International nursing review·N GeyerE Uys
Apr 23, 2008·Current Protocols in Neuroscience·Judith A Davis
May 18, 2020·Behavioural Brain Research·Shahin HassanpourSeyyed Mojtaba Razavi

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