Options for treating different soft tissue sarcoma subtypes

Future Oncology
Isabelle Ray-CoquardSebastian Bauer

Abstract

Management of soft tissue sarcoma is increasingly subtype-dependent. Surgery is recommended for uterine leiomyosarcoma, with trabectedin being the preferred option for advanced disease when the treatment goal is long-term tumor stabilization. Liposarcoma subgroups are characterized by distinctive morphologies and genetics, different patterns of disease progression and clinical behavior, and variable responses to treatment. Genetic analysis of sarcomas has provided insights into pathogenesis with potential for developing new molecular targets. At the cytogenetic level, soft tissue sarcomas are categorized into specific, balanced translocations and those due to massive chromosomal rearrangements. For subtypes such as undifferentiated sarcomas, angiosarcomas, alveolar soft part sarcomas and clear cell sarcomas, evidence is especially limited, although it is known that these tumors display markedly different sensitivities to chemotherapeutic and targeted agents.

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Citations

Aug 22, 2018·Expert Opinion on Drug Safety·Antonis A ManolisAntonis S Manolis
Nov 22, 2019·Veterinary and Comparative Oncology·Antonella BorgattiJessica Lawrence
Aug 14, 2020·Pituitary·Fernando Guerrero-PérezCarles Villabona
Oct 14, 2020·EMBO Molecular Medicine·Thomas Gp GrünewaldDominique Heymann
Nov 7, 2021·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·H ChenS Xiao

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Methods Mentioned

BETA
hysterectomy
surgical resections
exome sequencing
biopsy
bilateral oophorectomy
biopsies

Clinical Trials Mentioned

NCT01533207
NCT02275286
NCT03023124
NCT01391962
NCT03141684
NCT03016819
NCT02066285

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