Nov 2, 2018

Optoacoustic brains stimulation at submillimeter spatial precision

BioRxiv : the Preprint Server for Biology
Ying JiangJi-Xin Cheng

Abstract

Low-intensity ultrasound is an emerging modality for neuromodulation. Yet, piezo-based transducers offer poor spatial confinement of excitation volume, often bigger than a few millimeters in diameter. In addition, the bulky size limits their implementation in a wearable setting and prevents integration with other experimental modalities. Here, we report spatially confined optoacoustic neural stimulation through a novel miniaturized Fiber-Optoacoustic Converter (FOC). The FOC has a diameter of 600 μm and generates omnidirectional ultrasound wave locally at the fiber tip through the optoacoustic effect. We show that the optoacoustic wave can directly activate individual cultured neurons and generate intracellular Ca2+ transients. The FOC activates neurons within a radius of 500 μm around the fiber tip, delivering superior spatial resolution over conventional piezo-based low-frequency transducers. Combining FOC with electrophysiology, direct and spatially confined neural stimulation of mouse brain is achieved in vivo.

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Mentioned in this Paper

In Vivo
Size
Diagnostic Radiology Modality
Catheter Tip
Protoplasm
Neurons
Spatial Distribution
Brain
Calcium ion
Stimulation Procedure

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