Optochemical control of transcription by the use of 7-deaza-adenosine-based diarylethenes.

Chemical Communications : Chem Comm
Simon M BüllmannAndres Jäschke

Abstract

Out of nine different 7-deaza-adenosine diarylethenes, we identified a high-performance photoswitch, suitable for the synthesis of photochromic DNA. By using solid phase synthesis, a photoresponsive T7 promotor was generated which allowed reversibly modulating the rate of enzymatic RNA synthesis in vitro.

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Feb 13, 2021·Nature Biotechnology·Murat SunbulAndres Jäschke

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Citations

Sep 15, 2021·Chemistry : a European Journal·Theresa KolmarAndres Jäschke

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