Optofluidic microsystem with quasi-3 dimensional gold plasmonic nanostructure arrays for online sensitive and reproducible SERS detection

Analytica Chimica Acta
Yan DengQiuming Yu

Abstract

Practical applications of chemical and biological detections through surface-enhanced Raman scattering (SERS) require high reproducibility, sensitivity, and efficiency, along with low-cost, straightforward fabrication. In this work, we integrated a poly-(dimethylsiloxane) (PDMS) chip with quasi-3D gold plasmonic nanostructure arrays (Q3D-PNAs), which serve as SERS-active substrates, into an optofluidic microsystem for online sensitive and reproducible SERS detections. The Q3D-PNA PDMS chip was fabricated through soft lithography to ensure both precision and low-cost fabrication. The optimal dimension of the Q3D-PNA in PDMS was designed using finite-difference time-domain (FDTD) electromagnetic simulations with a simulated enhancement factor (EF) of 1.6×10(6). The real-time monitoring capability of the SERS-based optofluidic microsystem was investigated by kinetic on/off experiments through alternatively flowing Rhodamine 6G (R6G) and ethanol in the microfluidic channel. A switch-off time of ∼2 min at a flow rate of 0.3 mL min(-1) was demonstrated. When applied to the detection of low concentration malathion, the SERS-based optofluidic microsystem with Q3D-PNAs showed high reproducibility, significantly improved efficiency and h...Continue Reading

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Citations

Jan 19, 2016·Analytical and Bioanalytical Chemistry·Natalia Lopez-BarbosaJohann F Osma
Apr 8, 2017·The Veterinary Record
Apr 23, 2017·Electrophoresis·Anna TycovaFrantisek Foret
Feb 26, 2021·Journal of Separation Science·Ling Xia, Gongke Li
Jun 1, 2021·Comprehensive Reviews in Food Science and Food Safety·Zhaoda XieDa-Wen Sun
Sep 29, 2017·ACS Sensors·Onur DurucanAnja Boisen

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