Optogenetic approaches to investigate spatiotemporal signaling during development.

Current Topics in Developmental Biology
Katherine W Rogers, Patrick Müller

Abstract

Embryogenesis is coordinated by signaling pathways that pattern the developing organism. Many aspects of this process are not fully understood, including how signaling molecules spread through embryonic tissues, how signaling amplitude and dynamics are decoded, and how multiple signaling pathways cooperate to pattern the body plan. Optogenetic approaches can be used to address these questions by providing precise experimental control over a variety of biological processes. Here, we review how these strategies have provided new insights into developmental signaling and discuss how they could contribute to future investigations.

Citations

Aug 8, 2020·Cancers·Ludivine RabyPierre-Olivier Angrand
Nov 12, 2020·ELife·Katherine W RogersPatrick Müller
Aug 17, 2021·The EMBO Journal·Ranjith ViswanathanStefano De Renzis
Sep 23, 2021·Life Science Alliance·Theresa RauschendorferSabine Werner

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