Optogenetic Approaches to Restoring Vision

Annual Review of Vision Science
Zhuo-Hua PanGary W Abrams

Abstract

Severe loss of photoreceptor cells in inherited or acquired retinal degenerative diseases can result in partial loss of sight or complete blindness. The optogenetic strategy for restoration of vision utilizes optogenetic tools to convert surviving inner retinal neurons into photosensitive cells; thus, light sensitivity is imparted to the retina after the death of photoreceptor cells. Proof-of-concept studies, especially those using microbial rhodopsins, have demonstrated restoration of light responses in surviving retinal neurons and visually guided behaviors in animal models. Significant progress has also been made in improving microbial rhodopsin-based optogenetic tools, developing virus-mediated gene delivery, and targeting specific retinal neurons and subcellular compartments of retinal ganglion cells. In this article, we review the current status of the field and outline further directions and challenges to the advancement of this strategy toward clinical application and improvement in the outcomes of restored vision.

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Citations

Jan 28, 2017·Journal of Pediatric Ophthalmology and Strabismus·Frederick M Wang
Jul 19, 2018·Ophthalmic Surgery, Lasers & Imaging Retina·Benjamin BakallKendra A Klein
Feb 28, 2018·Lab Animal·Fabio Benfenati, Guglielmo Lanzani
May 1, 2019·Scientific Reports·Seokil MoonByoungho Lee
Feb 1, 2017·Advanced Biosystems·Arman AhnoodSteven Prawer
Feb 13, 2020·Investigative Ophthalmology & Visual Science·Ling-Jie CuiShi-Jun Weng
Mar 20, 2020·Physiological Reviews·Sonja KleinlogelTobias Moser
Oct 23, 2020·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Erica L Fletcher
Mar 14, 2021·The British Journal of Ophthalmology·Malena Daich VarelaMichel Michaelides

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Methods Mentioned

BETA
chip

Software Mentioned

eArchT3
ArchT
Chronos

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