Optogenetic approaches to vision restoration

Experimental Eye Research
M P SimunovicM C Gillies

Abstract

Inherited retinal disease (IRD) affects about 1 in 3000 to 1 in 5000 individuals and is now believed to be the most common cause of blindness registration in developed countries. Until recently, the management of such conditions had been exclusively supportive. However, advances in molecular biology and medical engineering have now seen the rise of a variety of approaches to restore vision in patients with IRDs. Optogenetic approaches are primarily aimed at rendering secondary and tertiary neurons of the retina light-sensitive in order to replace degenerate or dysfunctional photoreceptors. Such approaches are attractive because they provide a "causative gene-independent" strategy, which may prove suitable for a variety of patients with IRD. We discuss theoretical and practical considerations in the selection of optogenetic molecules, vectors, surgical approaches and review previous trials of optogenetics for vision restoration. Optogenetic approaches to vision restoration have yielded promising results in pre-clinical trials and a phase I/II clinical trial is currently underway (ClinicalTrials.gov NCT02556736). Despite the significant inroads made in recent years, the ideal optogenetic molecule, vector and surgical approach hav...Continue Reading

Citations

Mar 17, 2020·Current Opinion in Ophthalmology·Dominic A PradoRamiro S Maldonado
Jun 3, 2020·Advanced Materials·Daniel Boon Loong TehBrian K Kennedy
Apr 30, 2020·Anesthesiology·Eric D MelonakosKen Solt
Jul 3, 2020·Médecine sciences : M/S·Jean-Baptiste DucloyerMichel Weber
Jul 17, 2020·Journal of Clinical Medicine·Spencer M MooreDaniel L Chao
Dec 11, 2019·Cold Spring Harbor Perspectives in Biology·Emma L WestRobin R Ali
Jun 9, 2020·Asia-Pacific Journal of Ophthalmology·Mays Talib, Camiel J F Boon
Jul 1, 2020·Nature Nanotechnology·José Fernando Maya-VetencourtFabio Benfenati
Jun 6, 2020·Science·Katrin Franke, Anna Vlasits
Mar 7, 2019·Investigative and Clinical Urology·Eunkyoung Park, Kyu-Sung Lee
Nov 14, 2019·International Journal of Molecular Sciences·Alexander SumarokaSamuel G Jacobson
Jun 27, 2019·Human Molecular Genetics·Ivana Trapani, Alberto Auricchio
Sep 25, 2019·Genes·Jasmina Cehajic KapetanovicRobert E MacLaren
Sep 12, 2020·Ceská a slovenská oftalmologie : casopis Ceské oftalmologické spolecnosti a Slovenské oftalmologické spolecnosti·Z StraňákM Veith
Oct 7, 2020·Scientific Reports·Sophia Millington-WardG Jane Farrar
Oct 20, 2020·Frontiers in Neuroscience·Sabrina CarrellaSandro Banfi
Nov 17, 2020·Frontiers in Bioengineering and Biotechnology·José Fernando Maya-VetencourtFabio Benfenati
Jul 1, 2020·Advanced Drug Delivery Reviews·Wenhan Yu, Zhijian Wu
Mar 6, 2021·Molecular Therapy. Methods & Clinical Development·Elisa MurenuStylianos Michalakis
Mar 14, 2021·The British Journal of Ophthalmology·Malena Daich VarelaMichel Michaelides
Mar 23, 2021·Investigative Ophthalmology & Visual Science·Lorena Teixeira FrassonCarolina Beltrame Del Debbio
Apr 10, 2021·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Amithavikram R HathibelagalJohn L Barbur
Mar 20, 2019·Progress in Retinal and Eye Research·Giuliana GagliardiOlivier Goureau
Sep 30, 2021·International Ophthalmology Clinics·Michael T Massengill, Alfred S Lewin

❮ Previous
Next ❯

Related Concepts

Related Feeds

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

Related Papers

Advances in Experimental Medicine and Biology
Antoine Chaffiol, Jens Duebel
Current Opinion in Ophthalmology
Jens DuebelJosé-Alain Sahel
Science Translational Medicine
Hendrik P N SchollJosé-Alain Sahel
© 2022 Meta ULC. All rights reserved