Optogenetic Blockade of Dopamine Transients Prevents Learning Induced by Changes in Reward Features

Current Biology : CB
Chun Yun ChangGeoffrey Schoenbaum

Abstract

Prediction errors are critical for associative learning [1, 2]. Transient changes in dopamine neuron activity correlate with positive and negative reward prediction errors and can mimic their effects [3-15]. However, although causal studies show that dopamine transients of 1-2 s are sufficient to drive learning about reward, these studies do not address whether they are necessary (but see [11]). Further, the precise nature of this signal is not yet fully established. Although it has been equated with the cached-value error signal proposed to support model-free reinforcement learning, cached-value errors are typically confounded with errors in the prediction of reward features [16]. Here, we used optogenetic and transgenic approaches to prevent transient changes in midbrain dopamine neuron activity during the critical error-signaling period of two unblocking tasks. In one, learning was unblocked by increasing the number of rewards, a manipulation that induces errors in predicting both value and reward features. In another, learning was unblocked by switching from one to another equally valued reward, a manipulation that induces errors only in reward feature prediction. Preventing dopamine neurons in the ventral tegmental area fr...Continue Reading

Citations

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