Optogenetic deconstruction of sleep-wake circuitry in the brain.

Frontiers in Molecular Neuroscience
Antoine R AdamantidisLuis de Lecea

Abstract

How does the brain regulate the sleep-wake cycle? What are the temporal codes of sleep and wake-promoting neural circuits? How do these circuits interact with each other across the light/dark cycle? Over the past few decades, many studies from a variety of disciplines have made substantial progress in answering these fundamental questions. For example, neurobiologists have identified multiple, redundant wake-promoting circuits in the brainstem, hypothalamus, and basal forebrain. Sleep-promoting circuits have been found in the preoptic area and hypothalamus. One of the greatest challenges in recent years has been to selectively record and manipulate these sleep-wake centers in vivo with high spatial and temporal resolution. Recent developments in microbial opsin-based neuromodulation tools, collectively referred to as "optogenetics," have provided a novel method to demonstrate causal links between neural activity and specific behaviors. Here, we propose to use optogenetics as a fundamental tool to probe the necessity, sufficiency, and connectivity of defined neural circuits in the regulation of sleep and wakefulness.

Citations

Dec 21, 2011·Molecular Genetics and Genomics : MGG·Martin L Rein, Jan M Deussing
Dec 25, 2012·Journal of Neural Transmission·Paige BeckEdgar Garcia-Rill
Aug 20, 2014·Proceedings of the National Academy of Sciences of the United States of America·Peter BergmanTomas Hökfelt
Nov 28, 2015·Nature Reviews. Drug Discovery·Chenchen Song, Thomas Knöpfel
Feb 12, 2011·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Holly R Robertson, Guoping Feng
Sep 26, 2012·The International Journal of Neuroscience·Fengzhen HuangHong Jiang
Jun 26, 2013·Current Opinion in Neurobiology·Michael H Hastings, Michel Goedert
Apr 22, 2016·Scientific Reports·My AnderssonMerab Kokaia
Nov 5, 2014·Frontiers in Systems Neuroscience·Christin Kosse, Denis Burdakov
Dec 21, 2016·The Journal of Comparative Neurology·Lindsay J AgostinelliThomas E Scammell
Jan 21, 2017·Journal of Molecular Neuroscience : MN·Divya SachidanandanAmal Kanti Bera
Apr 17, 2013·Physiological Reviews·Björn Rasch, Jan Born
Mar 1, 2018·Pharmacological Reviews·Tobias AtkinGabriella Gobbi
Nov 28, 2013·Proceedings of the National Academy of Sciences of the United States of America·Robert M SearsJoseph E Ledoux
Jan 7, 2019·Brain Structure & Function·Lindsay J AgostinelliThomas E Scammell
Jul 22, 2017·Frontiers in Systems Neuroscience·Susan M Tyree, Luis de Lecea
Mar 19, 2019·Frontiers in Endocrinology·Gabriella Gobbi, Stefano Comai
Jan 1, 2021·BioMed Research International·Muhammed BishirDavid M Ojcius

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BETA
transgenic
imaging techniques

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