Optogenetic Inhibition of Ventral Pallidum Neurons Impairs Context-Driven Salt Seeking

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Stephen E ChangKyle S Smith

Abstract

Salt appetite, in which animals can immediately seek out salt when under a novel state of sodium deprivation, is a classic example of how homeostatic systems interface with learned associations to produce an on-the-fly updating of motivated behavior. Neural activity in the ventral pallidum (VP) has been shown to encode changes in the value of salt under such conditions, both the value of salt itself (Tindell et al., 2006) and the motivational value of its predictive cues (Tindell et al., 2009; Robinson and Berridge, 2013). However, it is not known whether the VP is necessary for salt appetite in terms of seeking out salt or consuming salt following sodium depletion. Here, we used a conditioned place-preference procedure to investigate the effects of optogenetically inhibiting the VP on context-driven salt seeking and the consumption of salt following deprivation. Male rats learned to associate one context with sucrose and another context with less-desirable salt. Following sodium depletion, and in the absence of either sucrose or salt, we found that inhibiting the VP selectively reduced the elevation in time spent in the salt-paired context. VP inhibition had minimal effects on the consumption of salt once it was made available...Continue Reading

Citations

May 18, 2018·Bio-protocol·Stephen E Chang, Kyle S Smith
Dec 15, 2019·Cognitive, Affective & Behavioral Neuroscience·Hammad A KhanKent C Berridge
Apr 21, 2020·The Journal of Comparative Neurology·Silvia GaspariniJoel C Geerling
Oct 22, 2018·Brain Structure & Function·Silvia GaspariniJoel C Geerling
Aug 28, 2020·Physiology & Behavior·Ileana Morales, Kent C Berridge
Jul 10, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·Shani GendelisYonatan M Kupchik
Sep 1, 2021·Proceedings of the National Academy of Sciences of the United States of America·Arndt-Lukas KlaassenGregor Rainer

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