Optogenetic manipulation of an ascending arousal system tunes cortical broadband gamma power and reveals functional deficits relevant to schizophrenia.

Molecular Psychiatry
James M McNallyRitchie E Brown

Abstract

Increases in broadband cortical electroencephalogram (EEG) power in the gamma band (30-80 Hz) range have been observed in schizophrenia patients and in mouse models of schizophrenia. They are also seen in humans and animals treated with the psychotomimetic agent ketamine. However, the mechanisms which can result in increased broadband gamma power and the pathophysiological implications for cognition and behavior are poorly understood. Here we report that tonic optogenetic manipulation of an ascending arousal system bidirectionally tunes cortical broadband gamma power, allowing on-demand tests of the effect on cortical processing and behavior. Constant, low wattage optogenetic stimulation of basal forebrain (BF) neurons containing the calcium-binding protein parvalbumin (PV) increased broadband gamma frequency power, increased locomotor activity, and impaired novel object recognition. Concomitantly, task-associated gamma band oscillations induced by trains of auditory stimuli, or exposure to novel objects, were impaired, reminiscent of findings in schizophrenia patients. Conversely, tonic optogenetic inhibition of BF-PV neurons partially rescued the elevated broadband gamma power elicited by subanesthetic doses of ketamine. Thes...Continue Reading

References

Jun 24, 1999·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·J VäisänenE Castrén
Nov 24, 1999·Archives of General Psychiatry·J S KwonR W McCarley
Dec 28, 1999·Proceedings of the National Academy of Sciences of the United States of America·R R LlinásP P Mitra
Jul 21, 2000·Biological Psychiatry·S Grossberg
Feb 5, 2002·Archives of General Psychiatry·Cenk TekRobert W Buchanan
Sep 6, 2003·Frontiers in Bioscience : a Journal and Virtual Library·Laszlo Zaborszky, Alvaro Duque
Nov 11, 2003·Genes, Brain, and Behavior·J L R Rubenstein, M M Merzenich
Mar 3, 2004·The American Journal of Psychiatry·Georg WintererDaniel R Weinberger
Aug 1, 2006·Biological Psychiatry·Jyrki AhveninenTyrone D Cannon
Jun 5, 2007·Biological Psychiatry·Elena V OrekhovaMikael Elam
Oct 18, 2008·Psychiatry Research·Timm RosburgJudith M Ford
Nov 14, 2008·Proceedings of the National Academy of Sciences of the United States of America·Houman Homayoun, Bita Moghaddam
Mar 19, 2009·Proceedings of the National Academy of Sciences of the United States of America·Benjamin Y HaydenMichael L Platt
Sep 4, 2009·Schizophrenia Bulletin·Colleen A BrennerBrian F O'Donnell
Oct 6, 2009·Nature Neuroscience·Michael Goard, Yang Dan
Feb 1, 2011·The Journal of Comparative Neurology·Patrick M FullerJun Lu
Mar 27, 2012·Annual Review of Neuroscience·György Buzsáki, Xiao-Jing Wang
Jun 26, 2012·Genes, Brain, and Behavior·M J GandalS J Siegel
Sep 27, 2012·Proceedings of the National Academy of Sciences of the United States of America·Alan AnticevicPhilip R Corlett
Nov 13, 2012·Trends in Cognitive Sciences·Alan AnticevicJohn H Krystal
Nov 28, 2012·Neuron·Andre M BastosKarl J Friston
Dec 21, 2012·The Journal of Comparative Neurology·James T McKennaRitchie E Brown
Nov 23, 2013·Nature Protocols·Marianne LegerThomas Freret
Dec 19, 2013·Current Pharmaceutical Design·Lakshmi RajagopalHerbert Y Meltzer
Jul 16, 2014·Frontiers in Neuroscience·Kazuhito Nakao, Kazu Nakazawa
Jan 4, 2015·The International Journal of Neuropsychopharmacology·Elyse M SullivanPatricio O'Donnell
Jan 15, 2015·JAMA Psychiatry·Yoji HiranoKevin M Spencer
Mar 4, 2015·Proceedings of the National Academy of Sciences of the United States of America·Tae KimRobert W McCarley
Mar 27, 2015·Annals of the New York Academy of Sciences·Digavalli V Sivarao
Aug 21, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Suresh D MuthukumaraswamyNeeraj Saxena
Oct 13, 2015·Nature Neuroscience·Min XuYang Dan
Oct 16, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shih-Chieh LinAdam Kepecs
Nov 4, 2015·Nature Communications·Christelle AnacletPatrick M Fuller

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Citations

Apr 29, 2021·Scientific Reports·David D AguilarJames M McNally
Aug 20, 2021·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Shinsuke KoikeYoji Hirano

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