Optogenetic Stimulation of Lateral Amygdala Input to Posterior Piriform Cortex Modulates Single-Unit and Ensemble Odor Processing

Frontiers in Neural Circuits
Benjamin Sadrian, Donald A Wilson

Abstract

Olfactory information is synthesized within the olfactory cortex to provide not only an odor percept, but also a contextual significance that supports appropriate behavioral response to specific odor cues. The piriform cortex serves as a communication hub within this circuit by sharing reciprocal connectivity with higher processing regions, such as the lateral entorhinal cortex and amygdala. The functional significance of these descending inputs on piriform cortical processing of odorants is currently not well understood. We have employed optogenetic methods to selectively stimulate lateral and basolateral amygdala (BLA) afferent fibers innervating the posterior piriform cortex (pPCX) to quantify BLA modulation of pPCX odor-evoked activity. Single unit odor-evoked activity of anesthetized BLA-infected animals was significantly modulated compared with control animal recordings, with individual cells displaying either enhancement or suppression of odor-driven spiking. In addition, BLA activation induced a decorrelation of odor-evoked pPCX ensemble activity relative to odor alone. Together these results indicate a modulatory role in pPCX odor processing for the BLA complex. This interaction could contribute to learned changes in P...Continue Reading

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Citations

Oct 1, 2016·Perception·Emmanuelle Courtiol, Donald A Wilson
Jul 16, 2016·Behavioural Brain Research·Nanette Y SchneiderGérard Coureaud
Mar 27, 2020·Frontiers in Behavioral Neuroscience·Ioannis KontarisDonald A Wilson
Jul 25, 2019·ELife·Guangyu ZhouChristina Zelano
Sep 2, 2018·Journal of Bioenergetics and Biomembranes·Jordan M Ross, Max L Fletcher
Oct 24, 2020·Journal of Neuroscience Methods·Sanaya K Stocke, Chad L Samuelsen
Oct 17, 2020·Cerebral Cortex·Zihao ZhangJoost X Maier

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Methods Mentioned

BETA
confocal microscopy

Software Mentioned

Spike2

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