Optogenetically induced low-frequency correlations impair perception

ELife
Anirvan NandyJ H Reynolds

Abstract

Deployment of covert attention to a spatial location can cause large decreases in low-frequency correlated variability among neurons in macaque area V4 whose receptive-fields lie at the attended location. It has been estimated that this reduction accounts for a substantial fraction of the attention-mediated improvement in sensory processing. These estimates depend on assumptions about how population signals are decoded and the conclusion that correlated variability impairs perception, is purely hypothetical. Here we test this proposal directly by optogenetically inducing low-frequency fluctuations, to see if this interferes with performance in an attention-demanding task. We find that low-frequency optical stimulation of neurons in V4 elevates correlations among pairs of neurons and impairs the animal's ability to make fine sensory discriminations. Stimulation at higher frequencies does not impair performance, despite comparable modulation of neuronal responses. These results support the hypothesis that attention-dependent reductions in correlated variability contribute to improved perception of attended stimuli.

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Citations

Oct 24, 2019·Journal of Neurophysiology·A AlishbayliB Englitz
Apr 7, 2020·Annual Review of Neuroscience·David A McCormickBiyu J He
Dec 25, 2019·Proceedings of the National Academy of Sciences of the United States of America·Yasmine El-Shamayleh, Gregory D Horwitz
Dec 10, 2019·Neuron·Yasaman BagherzadehRobert Desimone
Feb 18, 2021·Neuron·Leonhard WaschkeDouglas D Garrett
Oct 21, 2020·Neuron·Sébastien TremblayMichael L Platt
Dec 12, 2021·Proceedings of the National Academy of Sciences of the United States of America·Jacob A WesterbergAlexander Maier

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