Optogenetics gets to the heart: A guiding light beyond defibrillation

Progress in Biophysics and Molecular Biology
Claudia CrociniLeonardo Sacconi

Abstract

Optogenetics provides a tool for controlling the electrical activity of excitable cells by means of the interaction of light with light-gated ion channels. Despite the fact that optogenetics has been intensively utilized in the neurosciences, it has been more rarely employed as an instrument for studying cardiac pathophysiology. However, the advantages of optical approaches to perturb cardiac electrical activity are numerous, especially when the spatio-temporal qualities of light are utterly exploited. Here, we review the main breakthroughs employing optogenetics to perturb cardiac pathophysiology and attempt a comparison of methods and procedures that have employed optogenetics in the heart. We particularly focus on light-based defibrillation strategies that represent one of the latest achievements in this field. We highlight the important role of advanced optical methods for detecting and stimulating electrical activity for optimizing defibrillation strategies and, more generally, for dissecting novel insights in cardiac physiology. Finally, we discuss the main future perspectives that we envision for optogenetics in the heart, both in terms of translational applications and for addressing fundamental questions of cardiac fun...Continue Reading

References

Jul 1, 1975·The American Journal of Cardiology·D P ZipesW W Jolly
Oct 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·N R BlacklowW P Rowe
Feb 9, 2002·Science·David M BersonMotoharu Takao
Jun 29, 2002·Science·Georg NagelPeter Hegemann
Dec 14, 2002·Science·Satchidananda PandaSteve A Kay
Nov 15, 2003·Proceedings of the National Academy of Sciences of the United States of America·Georg NagelErnst Bamberg
Dec 22, 2005·Nature Biotechnology·Maria E BulinaKonstantin A Lukyanov
May 23, 2006·Molecular Therapy : the Journal of the American Society of Gene Therapy·Katsuya InagakiHiroyuki Nakai
Jul 29, 2006·Circulation Research·Christina A PacakBarry J Byrne
Oct 13, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Karl DeisserothMark J Schnitzer
Oct 24, 2007·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Arvydas MatiukasLeslie M Loew
Mar 20, 2009·Nature·Raag D AiranKarl Deisseroth
Mar 31, 2009·Journal of Cardiac Failure·Brian E JaskiUNKNOWN Calcium Up-Regulation by Percutaneous Administration of Gene Therapy In Cardiac Disease (CUPID) Trial Investigators
Oct 17, 2009·Science·Gero Miesenböck
Nov 17, 2009·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Ronan MargeyJames O'Neill
Oct 1, 2010·Nature Methods·Tobias BruegmannPhilipp Sasse
Oct 30, 2010·Nature Methods·Björn C Knollmann
Nov 13, 2010·Science·Aristides B ArrenbergJan Huisken
Apr 21, 2011·Proceedings of the National Academy of Sciences of the United States of America·André BerndtThomas G Oertner
Jun 29, 2011·Circulation·Mariell JessupUNKNOWN Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID) Investigators
Aug 11, 2011·Circulation. Arrhythmia and Electrophysiology·Zhiheng JiaEmilia Entcheva
Mar 28, 2012·Proceedings of the National Academy of Sciences of the United States of America·Leonardo SacconiFrancesco S Pavone
Jul 31, 2012·The Journal of Biological Chemistry·Matthias PriggePeter Hegemann
Nov 22, 2012·Proceedings of the National Academy of Sciences of the United States of America·Ping YanLeslie M Loew
Mar 5, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Emilia Entcheva
Jul 13, 2013·Cellular and Molecular Life Sciences : CMLS·C FerrantiniL Sacconi
Aug 29, 2013·Nature Communications·Patrick M BoyleNatalia A Trayanova
Sep 3, 2013·The Journal of Biological Chemistry·Elena G GovorunovaJohn L Spudich
Feb 1, 2014·Circulation Research·Xiulan YangCharles E Murry
Feb 11, 2014·Nature Methods·Nathan C KlapoetkeEdward S Boyden
Feb 13, 2014·Cardiovascular Research·Udi NussinovitchLior Gepstein
Mar 1, 2014·Cardiovascular Research·Thomas BeiertPhilipp Sasse
Mar 29, 2014·Science·Jonas WietekPeter Hegemann
May 6, 2014·Nature Methods·Sangkyu LeeWon Do Heo
May 24, 2014·Journal of Molecular and Cellular Cardiology·Marc N HirtThomas Eschenhagen
Jul 19, 2014·Progress in Biophysics and Molecular Biology·Christina M AmbrosiEmilia Entcheva
Jul 22, 2014·Nature Methods·Michaela MickoleitJan Huisken

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Citations

Jul 11, 2018·The Journal of Physiology·M ScardigliL Sacconi
Sep 2, 2017·Basic Research in Cardiology·Charlotte D KoopmanTeun P de Boer
Dec 20, 2020·Nature Reviews. Cardiology·Emilia Entcheva, Matthew W Kay
May 12, 2018·JACC. Clinical Electrophysiology·Patrick M BoyleNatalia A Trayanova

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